Lipopolysaccharide rapidly activates K+ channels at the intracellular membrane face of rat cerebral artery smooth muscle cells
Section snippets
Acknowledgements
This work was supported by a grant to D.A.M. from the Heart and Stroke Foundation of British Columbia and the Yukon.
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2019, Journal of Biological ChemistryCitation Excerpt :However, regulation of NF-κB translocation might not be the primary function of BK channels in activation of microglia, particularly primary microglia, because blockade of the BK channel after NF-κB translocation can still suppress the release of most of the downstream inflammatory factors. LPS has been reported to rapidly and directly activate BK channels at quite high concentrations (10–100 μg/ml) and with intracellular application in murine vascular smooth muscle cells (28, 29). Our results showed that in murine microglia LPS activates BK current at 100–1000-fold lower concentrations, and from the extracellular side, this effect can be inhibited by TLR4 antagonist CLI095, implying that LPS activates BK channels via TLR4.
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