Expression of 5-HT7 receptor mRNA in rat brain during postnatal development

https://doi.org/10.1016/S0304-3940(97)00302-9Get rights and content

Abstract

The present study is the first one to demonstrate the expression of 5-HT7 receptor mRNA by in situ hybridization during postnatal development. No quantitative developmental changes in the 5-HT7 gene expression was observed in neocortex, pyramidal layers of CA1 and CA2, dentate gyrus, most of thalamic nuclei, mammillary region, superior colliculus and central gray. However, in retrosplenial cortex, subiculum and medial habenula an increase of labeling is observed between postnatal days (PN) PN15 and PN21. Striatum showed a transient expression during the first stages of development to be undetectable in adults. CA3 pyramidal cell layer, intramediodorsal thalamic nucleus and lateral habenula displayed a high mRNA expression at PN5 and PN8 which decreased throughout development but it was still present in adults. A possible non-neurotransmitter throphic function of 5-HT mediated through 5-HT7 receptors could be suggested.

Section snippets

Acknowledgements

This work was supported by grant CICYT SAF 95-0615. M.L. Vizuete and J.L. Venero thank the Spanish Ministerio de Educación y Ciencia for a Contrato de Investigación.

References (20)

There are more references available in the full text version of this article.

Cited by (48)

  • Co-activation of both 5-HT <inf>1A</inf> and 5-HT <inf>7</inf> receptors induced attenuation of glutamatergic synaptic transmission in the rat visual cortex

    2018, Neuroscience Letters
    Citation Excerpt :

    With the increase of age, the expression of the 5-HT1A -5-HT7 heterodimer was gradually reduced, progressively permitting 5-HT1A monomers and homodimers to become the dominant populations [16]. Moreover, a previous study has reported that 5-HT1A receptors were poorly expressed immediately after birth in the developing visual cortex, but that their expression increased rapidly during the postnatal development of the rat [5], while 5-HT7 receptors remain stably expressed [21,22]. The presence of 5-HT1A receptors, 5-HT7 receptors and 5-HT1A -5-HT7 heterodimers in the developing rat visual cortex suggests that a direct interaction between 5-HT1A receptors and 5-HT7 receptors significantly attenuate glutamatergic synaptic transmission by activating their downstream signaling pathways.

  • The lateral habenula and the serotonergic system

    2017, Pharmacology Biochemistry and Behavior
    Citation Excerpt :

    Moreover, it has been shown that the varicosities of the fine axons rarely make synaptic contacts (Séguéla et al., 1989), while larger varicosities found on the thicker axons tend to show synaptic specializations (Törk, 1990). Several types of 5-HT receptors have now been identified in the LHb, including 5-HT1, 5-HT2, 5-HT3, 5-HT5, and 5-HT7 receptors (Pompeiano et al., 1994; Sari et al., 1997; Vizuete et al., 1997; for a recent excellent mini review, see Tchenio et al., 2016). As revealed by microarray, in-situ hybridization, and/or immunohistochemical methods, specifically the 5-HT1B, 5-HT2A, and 5-HT2C (Aizawa et al., 2012) subtypes show an elevated expression in the LHb compared to the surrounding MHb and thalamus (Wagner et al., 2016).

  • Adolescent male rats are less sensitive than adults to the anxiogenic and serotonin-releasing effects of fenfluramine

    2013, Neuropharmacology
    Citation Excerpt :

    Animal studies suggest that forebrain serotonergic function during early adolescence may be lower than in adults, especially in the cortex. While serotonin receptor expression, dorsal raphe firing rates, and the anatomic pattern of serotonergic innervation appear to be mature by adolescence, neurochemical markers of presynaptic serotonergic function increase between adolescence and adulthood (Beique et al., 2004; Daval et al., 1987; Garcia-Alcocer et al., 2006; Lanfumey and Jacobs, 1982; Lidov and Molliver, 1982; Miquel et al., 1994; Pranzatelli and Galvan, 1994; Vizuete et al., 1997; Waeber et al., 1996, 1994). Serotonin transporter (SERT) binding is lower in the cortex of early adolescent rats (PN28–35), and some studies show lower SERT binding in subcortical regions such as the amygdala and striatum (Dao et al., 2011; Galineau et al., 2004; Moll et al., 2000; Tarazi et al., 1998).

View all citing articles on Scopus
View full text