Elsevier

Neuroscience Letters

Volume 323, Issue 2, 26 April 2002, Pages 93-96
Neuroscience Letters

The effect of orexin-A and -B on the histamine release in the anterior hypothalamus in rats

https://doi.org/10.1016/S0304-3940(01)02552-6Get rights and content

Abstract

The neuropeptides orexin-A and -B have been reported to be appetite-stimulating peptides, but they are also known as important factors that control arousal state. We studied the effects of orexin-A and -B on the hypothalamic histamine release using in vivo microdialysis. A significant and sustained increase in histamine release was observed by intracerebroventricular injection of 1 nmol of orexin-A, but not by the same dose of orexin-B. An increased dose of orexin-B to 5 nmol facilitated histamine release, although this effect was much less potent than orexin-A. These findings suggest that both of the orexins play important roles in the regulation of waking through the activation of histaminergic system.

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