The effect of orexin-A and -B on the histamine release in the anterior hypothalamus in rats
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Cited by (47)
Emerging role of orexin antagonists in insomnia therapeutics: An update on SORAs and DORAs
2016, Pharmacological ReportsCitation Excerpt :For example, studies reveal that orexin-1 microinjections into the rat's BF increases cortical acetylcholine release. Also, intracerebroventricular delivery of orexin-1 has been found to increase histamine levels in rodent frontal cortex and anterior hypothalamus [49–51]. Furthermore, microinjection of orexin-1 into other arousal modulating brain regions, like the VTA, the DR nucleus, and pontine reticular formation increases dopamine, serotonin and acetylcholine release respectively [52–54].
Intracerebroventricular injection of orexin-2 receptor antagonist promotes REM sleep
2013, Behavioural Brain ResearchNeuropharmacology of sleep and wakefulness: 2012 update
2012, Sleep Medicine ClinicsCitation Excerpt :Microinjection of hypocretin-1 into the basal forebrain of rats increases cortical acetylcholine release.185 Intracerebroventricular delivery of hypocretin-1 increases histamine in rodent frontal cortex186 and anterior hypothalamus.187 Microinjection of hypocretin-1 into the ventricles or the ventral tegmental area increases dopamine release in rat prefrontal cortex.178
Action of Modafinil Through Histaminergic and Orexinergic Neurons
2012, Vitamins and HormonesCitation Excerpt :Figure 14.1 shows microdialysis data which studied the effects of orexins on hypothalamic histamine release in rats. The intracerebroventricular injections of both orexin peptides significantly increase histamine release in the rat anterior hypothalamus, although a fivefold dose of orexin-B (5 nmol) is required to achieve an effect equivalent to that of orexin-A (1 nmol) on histamine release (Fig. 14.1; Ishizuka et al., 2002). Huang et al. (2001) also reported that direct perfusion of orexin-A into the TMN enhanced waking time concomitant with a reduction of slow-wave sleep and REM sleep and increased histamine release in the medial preoptic area and the frontal cortex.
Neuropharmacology of sleep and wakefulness
2010, Sleep Medicine ClinicsCitation Excerpt :Microinjection of hypocretin-1 into the basal forebrain of rat increases cortical acetylcholine release.170 Intracerebroventricular delivery of hypocretin-increases histamine in rodent frontal cortex171 and anterior hypothalamus.172 Microinjection of hypocretin-1 into the ventricles or the ventral tegmental area increases dopamine release in rat prefrontal cortex.163
Modanifil activates the histaminergic system through the orexinergic neurons
2010, Neuroscience Letters