Cancer Letters

Cancer Letters

Volume 114, Issues 1–2, 19 March 1997, Pages 145-151
Cancer Letters

Measurement and metabolism of isoflavonoids and lignans in the human male

https://doi.org/10.1016/S0304-3835(97)04646-6Get rights and content

Abstract

Asian men, who consume a low fat/high fibre soya-based diet, have very much lower incidence of prostate cancer than men from North America and Europe. The soya bean is a rich source of the isoflavonic phyto-oestrogens, daidzein, genistein and equol, compounds which may be cancer-protective in Asian populations. The lignans, enterolactone and enterodiol, plant oestrogens derived from cereals and vegetables, may act in a similar manner in vegetarian men. We report here on the measurement of isoflavonoids and lignans, by gas chromatography-mass spectrometry, in prostatic fluid of men from Asia and Europe and also on the metabolism of these compounds in Western men following dietary supplementation.

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