Specific postoperative syndromes after total and selective vagotomies in the rat1
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Cited by (72)
The controversial role of the vagus nerve in mediating ghrelin's actions: gut feelings and beyond
2022, IBRO Neuroscience ReportsCitation Excerpt :Surgical vagotomy is a classical strategy to physically interrupt vagal fibers. Surgical vagotomy includes either total (bilateral) subdiaphragmatic vagotomy, which leads to severe hypophagia and body weight loss and requires the use of liquid diets to minimize post-vagotomy symptoms, or selective vagotomy such as gastric vagotomy that has less severe consequences (Kraly et al., 1986). Importantly, vagotomy abolishes afferent and efferent transmissions and, consequently, it does not allow to study their differential roles.
Impaired vagus function in rats suppresses bile acid synthesis in the liver by disrupting tight junctions and activating Fxr-Fgf15 signaling in the intestine
2018, Biochemical and Biophysical Research CommunicationsCitation Excerpt :The surgery in the Sham group followed precisely the same procedure as in the vagotomy group, but the vagus nerve was left intact. Body weights were monitored throughout the study because loss of body weight is an indicator for a successful vagotomy surgery [11,12]. On the seventh day after surgery, rats were anesthetized with pentobarbital sodium (50 mg/kg, i.p.) and the common bile duct of each rat was cannulated with a 30-gauge needle attached to PE-10 tubing.
Cognitive effects of subdiaphragmatic vagal deafferentation in rats
2017, Neurobiology of Learning and MemoryCitation Excerpt :To date, it is the most complete and selective vagal deafferentation method for all abdominal visceral fibers and critically differs from total subdiaphragmatic vagotomy (TVX) models, the latter of which leads to a disconnection of both the afferent and efferent fibers of the vagus nerve below the diaphragm (Bercik et al., 2011; Bravo et al., 2011). Unlike TVX (Kraly, Jerome, & Smith, 1986), SDA allows for a discrimination of the relative functional contribution of vagal afferents versus efferents in the absence of severe side effects such as disturbances in gastrointestinal motility and secretion, hypophagia and subsequent body weight loss (Arnold et al., 2006; Azari et al., 2014; Klarer et al., 2014). Based on the reported effects of VNS on working memory (Beste et al., 2016), recognition memory (Clark et al., 1999), and cognitive flexibility (Ghacibeh, Shenker, Shenal, Uthman, & Heilman, 2006a), we compared the performance of SDA and Sham-operated rats in these cognitive domains.
Vagal mediation of GLP-1's effects on food intake and glycemia
2015, Physiology and BehaviorGut vagal afferents are necessary for the eating-suppressive effect of intraperitoneally administered ginsenoside Rb1 in rats
2015, Physiology and BehaviorCitation Excerpt :SDA is a surgical procedure, which eliminates all neuronal signals mediated via vagal afferent fibers from the upper gut, including the liver, while leaving half of the vagal efferent fibers intact [19,6]. Therefore, different from what occurs with gastric vagotomy, which inevitably blocks gut vagal efferent traffic and often produces gastrointestinal motor and secretory dysfunction, anorexia, and malnutrition in both rats and humans [26,27], SDA has less side effects that might interfere with the normal control of food intake and consequently affect the results of Rb1 treatment. In the present study, we attempted to maximize the validity of our tests by including only data from animals that passed stringent functional criteria for complete lesions.
Subdiaphragmatic vagotomy promotes nociceptive sensitivity of deep tissue in rats
2009, NeuroscienceCitation Excerpt :Although no significant change in body weight at baseline between groups (347±14 g vs. 350±10 g, P=0.59; subdiaphragmatic vagotomy vs. sham) were found, the apparent decrease of body weight following subdiaphragmatic vagotomy was observed from day 3 (339±10 g vs. 377±5 g, P=0.004; subdiaphragmatic vagotomy vs. sham) to day 28 (427±12 g vs. 481±8 g, P=0.003; subdiaphragmatic vagotomy vs. sham) after operation. This result was consistent with those in previous reports (Opsahl and Powley, 1977; Kraly et al., 1986), which indicates that the operation was successful. The baseline withdrawal threshold was similar in sham-operated and subdiaphragmatic vagotomized rats.
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This research was supported by NIMH grant MH15455 and Career Scientist Award MH00149 (to G.P.S.), a NIH New Investigator Research Award NS19133 (to F.S.K.) and a Colgate University Carter-Wallace Fellowship (29-012-60-16).