In vitro permeability of peptidomimetic drugs: The role of polarized efflux pathways as additional barriers to absorption
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Oral colon delivery of insulin with the aid of functional adjuvants
2012, Advanced Drug Delivery ReviewsCitation Excerpt :However, this is mostly evoked by specific receptor/ligand interactions. In addition to the difficulties encountered in crossing the mucosal barrier, polarized efflux systems located in the apical membrane could participate in limiting the absorption of these drugs [97,98]. Mainly hydrophobic peptides, e.g. the immunosuppressant cyclosporin A and cyclopeptidic macrolactone antibiotic pristinamycin IA, might indeed be removed from the cell by P-glycoprotein and multi-drug resistance-associated protein, which would be responsible for non-biliary intestinal excretion of a variety of structurally unrelated compounds.
Synthesis of new class dipeptide analogues with improved permeability and antithrombotic activity
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