Trends in Pharmacological Sciences
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A novel Danshensu/tetramethylpyrazine derivative induces vasorelaxation on rat aorta and exerts cardioprotection in dogs
2018, European Journal of PharmacologyThe role of STIM1 and SOCE in smooth muscle contractility
2017, Cell CalciumCitation Excerpt :A series of studies (summarized in Table 1) performed prior to the molecular identification of STIM1 and Orai1 suggest a role for capacitative Ca2+ entry in regulating vascular smooth muscle (VSM) contractility and tone [31,37–42]. The specific contribution of SOCCs (versus VOCCs) to Ca2+ flux is vessel dependent [31]. For example, SOCCs appear to contribute little to aortic smooth muscle Ca2+ flux; in aortic rings harvested from rats, CPA-induced Ca2+ flux was abolished by the voltage-sensitive Ca2+ channel blocker nifedipine [38,39,42].
Systems-biology dissection of mechanisms and chemical basis of herbal formula in treating chronic myocardial ischemia
2016, Pharmacological ResearchParticipation of the TRP channel in the cardiovascular effects induced by carvacrol in normotensive rat
2015, Vascular PharmacologyElevated maxi-K<sup>+</sup> ion channel current in glaucomatous lamina cribrosa cells
2013, Experimental Eye ResearchCitation Excerpt :This pathway provides a means to refill the Ca2+ stores. More evidence suggests that this pathway may also be important in the regulation of vascular tone (Gibson et al., 1998). In the eye, maxi-K+ channels in bovine trabecular meshwork cells are activated by cell membrane stretch (Gasull et al., 2003).