Trends in Pharmacological Sciences
Review5-HT2 receptor subtypes: A family re-united?
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2017, Progress in NeurobiologyContractile effects of 3,4-methylenedioxymethamphetamine on the human internal mammary artery
2016, Toxicology in VitroCitation Excerpt :Tanaka and colleagues, by functional and immunohistochemical studies, also characterized 5-HT2A and 5-HT1B receptors in smooth muscle cells of this vessel (Tanaka et al., 2008). The now observed contractile effect of MDMA, in the human internal mammary artery, is in accordance with the above described findings since ketanserin, a selective 5-HT2A/2C antagonist (pKi of 8.9 and 7.0 at 5-HT2A and 5-HT2C receptors) (Baxter et al., 1995) altered both MDMA and 5-HT concentration-response curves, almost abolishing the 5-HT maximum contraction, making the 5-HT-induced contractile effect in this vessel almost mediated by this subtype receptor, similarly to what was reported on other peripheral non intracranial blood vessels, namely the human uterine artery (Karlsson et al., 1997). An antagonism at 5-HT2C receptors is most unlikely, since they have not yet been described in the cardiovascular system (Hoyer et al., 1994; Watts and Davis, 2011).