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Anandamide: an endogenous activator of the vanilloid receptor

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Chemical name

AM404:
(all z)-N-(4-hydroxyphenyl)-5,8,11,14-eicosatetraenamide

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Cited by (94)

  • Cannabinoid pharmacology in cancer research: A new hope for cancer patients?

    2016, European Journal of Pharmacology
    Citation Excerpt :

    Recent advances suggest, at least for AEA, that the transient receptor potential vanilloid 1 receptor (TRPV1) channel may be considered as the “third” receptor involved in endocannabinoid signalling (Di Marzo et al., 2001; Ross, 2003). For example, it has been shown that the endocannabinoids exert their apoptotic effect by binding to TRPV1, a non-selective cation channel targeted by capsaicin, the active component of hot chilli peppers (Smart and Jerman, 2000). However, the precise role of this receptor in cannabinoid signalling is still unclear and this uncertainty extends into the cancer field where its potential role in cancer biology (proliferation and migration of cancer cells) and cancer pharmacology (resistance to chemotherapeutic agents) needs further investigation (Lehen'kyi and Prevarskaya, 2011; Liberati et al., 2013).

  • Modulation of defensive behavior by Transient Receptor Potential Vanilloid Type-1 (TRPV1) Channels

    2014, Neuroscience and Biobehavioral Reviews
    Citation Excerpt :

    The most studied endovanilloid is, by far, anandamide (N-arachidonoyl ethanolamine), an arachidonic acid derived neuromodulator. Anandamide is primarily known as the endogenous agonist at the CB1 receptors, being the first described endocannabinoid/endovanilloid (Di Marzo et al., 2001; Smart and Jerman, 2000; Zygmunt et al., 2000). Other proposed endovanilloids are N-arachidonoyl dopamine (Huang et al., 2002; Toth et al., 2003), N-oleoyl dopamine (Chu et al., 2003) and some products of lipoxygenases, such as 12-HPETE (12-hydroperoxyeicosatetraenoic acid) and leukotriene B4 (Hwang et al., 2000).

  • The endocannabinoid and endovanilloid systems interact in the rat prelimbic medial prefrontal cortex to control anxiety-like behavior

    2012, Neuropharmacology
    Citation Excerpt :

    As for the bell-shaped effects, they could depend on several mechanisms. For example, i) endocannabinoids are synthesized on demand and their effect may be influenced by environmental factors such as stress levels (Tasker, 2004); ii) the endocannabinoid system shows a wide neuroanatomical distribution and modulates neurotransmitter systems that can play opposite roles in anxiety, such as glutamate and GABA (Moreira and Lutz, 2008; Ross, 2003); iii) anandamide can also activate other receptors such as TRPV1 (Zygmunt et al., 1999; Smart et al., 2000; Smart and Jerman, 2000). These receptors can facilitate defensive behaviors (Starowicz et al., 2008; Di Marzo et al., 2008) by increasing calcium influx and glutamate and nitric oxide release (Starowicz et al., 2007; Musella et al., 2009; Zschenderlein et al., 2011) and have been described in the pre- and infralimbic cortices (de Novellis et al., 2011).

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