ROLE OF CHOLECYSTOKININ IN REGULATION OF GASTROINTESTINAL MOTOR FUNCTIONS
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Cited by (213)
Potential functional and pathological side effects related to off-target pharmacological activity
2017, Journal of Pharmacological and Toxicological MethodsProhormone convertase 7 is necessary for the normal processing of cholecystokinin in mouse brain
2017, Biochemical and Biophysical Research CommunicationsCitation Excerpt :CCK has numerous physiological functions. In the gastrointestinal (GI) system it is important for contraction of the gallbladder, secretion of pancreatic enzymes and motility of the GI tract [1–4]. In the mammalian brain, CCK is one of the most abundant neuropeptides [5–7].
Plasminogen activator inhibitor (PAI)-1 suppresses inhibition of gastric emptying by cholecystokinin (CCK) in mice
2013, Regulatory PeptidesCitation Excerpt :A number of different neuro-endocrine control mechanisms have been identified that act either to change the pressure difference across the pylorus, for example by relaxation of the gastric corpus, or by changing the resistance to flow across the pylorus. The role of the intestinal hormone cholecystokinin (CCK) as a physiological regulator of the gastric emptying of protein and fat has been relatively well studied since its discovery in the mid-1970s [1–5]. Dietary protein and fatty acids with a chain length greater than C12 release CCK which in turn regulates protein and lipid digestion by stimulating delivery to the duodenum of bile salts (through stimulation of gall bladder contraction) and pancreatic enzymes (through stimulation of pancreatic acinar cell exocytosis) [6].
Current and novel therapeutic options for irritable bowel syndrome management
2009, Digestive and Liver DiseaseCitation Excerpt :Loxiglumide and Dexloxiglumide: Loxiglumide is a highly specific, competitive antagonist of the CCK1 receptor [92]. Earlier pharmacodynamic [93] and clinical [94] studies suggested that loxiglumide might improve constipation. A 12-week, phase II trial of 200 mg/day dexloxiglumide [95] in female IBS-C patients showed improvement in abdominal pain and discomfort compared to placebo, but two large phase III trials in IBS-C showed no efficacy for dexloxiglumide [96].
The effects on diet, anastomotic type, and loxiglumide on gastric emptying following gastrojejunostomy
2009, International Journal of SurgeryCitation Excerpt :Cholecystokinin (CCK), which is a gastrointestinal peptide secreted after meals, has a major role in the regulation of gastric motor function.6–8 It was shown that an infusion of CCK delays gastric emptying and that blockage of CCK receptors with a specific antagonist such as loxiglumide can reduce it.9–12 In our experimental study, we investigated the effects of diet and loxiglumide administration on gastric emptying after antecolic and retrocolic gastrojejunostomy in rats, using solid phase scintigraphy which is the gold standard for measuring gastric emptying.13
Role of fat hydrolysis in regulating glucagon-like peptide-1 secretion
2010, Journal of Clinical Endocrinology and Metabolism