Cell
Volume 108, Issue 1, 11 January 2002, Pages 31-43
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Article
DREAM Is a Critical Transcriptional Repressor for Pain Modulation

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Abstract

Control and treatment of chronic pain remain major clinical challenges. Progress may be facilitated by a greater understanding of the mechanisms underlying pain processing. Here we show that the calcium-sensing protein DREAM is a transcriptional repressor involved in modulating pain. dream−/− mice displayed markedly reduced responses in models of acute thermal, mechanical, and visceral pain. dream−/− mice also exhibited reduced pain behaviors in models of chronic neuropathic and inflammatory pain. However, dream−/− mice showed no major defects in motor function or learning and memory. Mice lacking DREAM had elevated levels of prodynorphin mRNA and dynorphin A peptides in the spinal cord, and the reduction of pain behaviors in dream−/− mice was mediated through dynorphin-selective kappa (κ)-opiate receptors. Thus, DREAM appears to be a critical transcriptional repressor in pain processing.

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These authors contributed equally to the manuscript.