Structure-activity studies on amphetamine analogs using drug discrimination methodology
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Enantioseparation and a comprehensive spectroscopic analysis of novel synthetic cathinones laterally substituted with a trifluoromethyl group
2023, Spectrochimica Acta - Part A: Molecular and Biomolecular SpectroscopyAbuse-related neurochemical and behavioral effects of cathinone and 4-methylcathinone stereoisomers in rats
2016, European NeuropsychopharmacologyCitation Excerpt :The present results are consistent with previous evidence for stereoselectivity in potency but not quality of pharmacological effects for cathinone. For example, previous studies found that both S(−) and R(+)cathinone promote DA release from rat brain striatal slices (Kalix, 1986) and substitute for S(+)amphetamine in rats trained to discriminate amphetamine from saline (Glennon et al., 1984), and in both of these studies, S(−)cathinone was more potent than R(+)cathinone. In addition, the present study found that both cathinone enantiomers facilitated ICSS, and drug-induced facilitation of ICSS is often interpreted as an abuse-related behavioral effect that correlates both with expression of drug reinforcement in preclinical assays of drug self-administration and with abuse potential in humans (Negus and Miller, 2014).
Alpha-ethyltryptamines as dual dopamine-serotonin releasers
2014, Bioorganic and Medicinal Chemistry LettersSynthetic cathinones: Chemical phylogeny, physiology, and neuropharmacology
2014, Life SciencesCitation Excerpt :What we now know as cathinone was coincidentally shown to be a locomotor stimulant in 1962. Various other studies over the ensuing years concluded that, like amphetamine, cathinone and several related cathinone analogs are DA releasing agents (Kalix and Glennon, 1986; Glennon et al., 1987), that both optical isomers of cathinone substitute for training drug in rats trained to discriminate (+)amphetamine from vehicle, that stimulus generalization could be blocked by haloperidol (Glennon et al., 1984a), and that cathinone itself could be used as a training drug in drug discrimination studies using rats as subjects (Glennon et al., 1984a, 1984b; Schechter and Glennon, 1985). In these, and other, investigations S(−)cathinone was found more potent that R(+)cathinone just as S(+)amphetamine is more potent than R(−)amphetamine.
Bath salts, mephedrone, and methylenedioxypyrovalerone as emerging illicit drugs that will need targeted therapeutic intervention
2014, Advances in PharmacologyCitation Excerpt :S(−)Methcathinone, but not S(+)METH, substituted in (−)ephedrine-trained rats (Bondareva, Young, & Glennon, 2002). With racemic cathinone as the training drug, stimulus generalization occurred to both cathinone optical isomers (S > R), cathine, (+)AMPH, METH, and cocaine, but not to α-desmethylcathinone, 4-hydroxycathinone, 4-methoxycathinone, or 4-chlorocathinone (Glennon, Schechter, et al., 1984; Glennon, Young, et al., 1984; Schechter & Glennon, 1985), nor 4-fluorocathinone (unpublished data). Likewise, (+)AMPH, cocaine, cathine, but not α-desmethylcathinone, substituted in cathinone-trained rats (Goudie, Atkinson, & West, 1986).
Aminoindane Analogues
2013, Novel Psychoactive Substances: Classification, Pharmacology and Toxicology