PDE4 cAMP-specific phosphodiesterases
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PDE4DIP in health and diseases
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2020, Gene ReportsPhosphodiesterase-4 Inhibitor Roflumilast Attenuates Pulmonary Air Emboli–Induced Lung Injury
2019, Journal of Surgical ResearchCitation Excerpt :Type 4 PDE (PDE4) is found in most inflammatory cells, such as neutrophils and lymphocytes. PDE4 is the main PDE involved in regulating inflammation,5,7 and therefore, it is expected to be critical in ALI related to PAE. PAE-induced ALI often expresses with lung edema, neutrophilic sequestration, pulmonary vascular hyperpermeability, and cytokines release.4
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