Chapter 35 Serotonin brain circuits involved in major depression and suicide
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Novel serotonin-boosting effect of incense smoke from Kynam agarwood in mice: The involvement of multiple neuroactive pathways
2021, Journal of EthnopharmacologySex difference in the association between physical activity and suicide attempts among adolescents from 48 countries: A global perspective
2020, Journal of Affective DisordersCitation Excerpt :Recent meta-analyses have shown that engagement in physical activity decreases risk for depression (Bailey et al., 2018; Korczak et al., 2017), which is an established risk factor for SA and completed suicides (Peyre et al., 2017; Carballo et al., 2019). It has been hypothesized that physical activity leads to enhanced mood and thereby protects against depression via several biological mechanisms such as anti-inflammatory effects, regulations in the hypothalamic-pituitary adrenal axis, neurotransmitter release regulations and increases of monoamine levels (i.e., serotonin), increases in brain volume (i.e., hippocampal volume anterior cingulate cortex, prefrontal cortex), and increase in circulating levels of neurotrophic factors (Mahar et al., 2014; Silverman and Deuster, 2014; Arango et al., 2002; Gujral et al., 2017; Lin and Kuo, 2013). Nonetheless, the majority of evidence supporting these pathways are derived from older adults and clinical populations.
Crh receptor priming in the bed nucleus of the stria terminalis (BNST) induces tph2 gene expression in the dorsomedial dorsal raphe nucleus and chronic anxiety
2020, Progress in Neuro-Psychopharmacology and Biological PsychiatryCitation Excerpt :Emotional disorders, such as social anxiety disorder (SAD), cause significant suffering and are a costly health care burden to society. While both stress-responsive systems and serotonin (5-hydroxytryptamine; 5-HT) systems are often dysregulated in these and other psychiatric disorders (Arango et al., 2002; Gillespie and Nemeroff, 2005), additional research is needed to determine how these systems interact to induce chronic anxiety-like states. Susceptibility to stress-related plasticity changes in the brain are determined by inherited genetic factors as well as environmental factors, such as adverse events or chronic stressors (Kendler et al., 2004).
Dual pharmacological inhibitor of endocannabinoid degrading enzymes reduces depressive-like behavior in female rats
2020, Journal of Psychiatric Research