Effects of dynorphins on body temperature of rats
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Cited by (20)
Role of preoptic opioid receptors in the body temperature reduction during hypoxia
2009, Brain ResearchCitation Excerpt :However, this effect may be dependent on the specific receptor subtypes activated during hypoxia. At least in normoxia, the activation of mu-opioid receptors, by icv injection of PL-017, DAGO and DAMGO, increases Tb (Handler et al., 1992; Spencer et al., 1988) and selected ambient temperature of rats in a thermal gradient (Spencer et al., 1990), while the activation of kappa-opioid receptors by icv injection of dynorphin and U50,488H causes the opposite effect, i.e., decrease in Tb (Cavicchini et al., 1988; Spencer et al., 1988) and in selected temperature (Spencer et al., 1990). As to delta-opioid receptors, there are conflicting reports of icv injected agonists that produce hypothermia (D-ala-deltorphin II), no effect or hypothermia followed by hyperthermia (DPDPE) (Broccardo and Improta, 1992; Handler et al., 1992; Spencer et al., 1988).
Physiology of temperature regulation: Comparative aspects
2007, Comparative Biochemistry and Physiology - A Molecular and Integrative PhysiologyFunctional interactions between δ- and μ-opioid receptors in rat thermoregulation
2003, European Journal of PharmacologyCitation Excerpt :Evidence from work with selective opioid receptor agonists and antagonists in rats indicates that all three opioid receptors indeed are involved in thermoregulation. Activation of μ-opioid receptors produces hyperthermia (Spencer et al., 1988; Handler et al., 1992) while activation of κ-opioid receptors induces hypothermia (Cavicchini et al., 1988; Spencer et al., 1988). In support of a specific role of δ-opioid receptors in thermoregulation, electrophysiological experiments have demonstrated specific effects by δ-opioid receptor agonists and antagonists on thermosensitive neurons expressing δ-opioid receptors within the preoptic area of the anterior hypothalamus (Yakimova et al., 1998).
Role of L-type Ca<sup>2+</sup> channels in pertussis toxin induced antagonism of U50,488H analgesia and hypothermia
2002, Brain ResearchCitation Excerpt :The κ-opioid receptor agonists are potent analgesics with minimal respiratory depression and physical dependence [27]. However, in addition to analgesia, κ-opioid agonists also produce hypothermia [3,5,14,16,30,36]. Several studies have used PTX pretreatment as a tool to assess the role of G-protein mediated events on the pharmacodynamics of morphine.