Rapid communicationFunctional coexpression of excitatory mGluR1 and mGluR5 on striatal cholinergic interneurons
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Acknowledgments
The technical help of Mr M. Tolu is gratefully acknowledged. This work was supported by Ministero Sanità (Finalizzato) and MURST (Cofinanziamento) grants to A.P. and G.B., respectively.
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2008, NeuropharmacologyCitation Excerpt :Electrophysiological data are in support of a functional co-expression of both group I mGlu receptors. Indeed, in this neuronal subtype the activation of either group I mGlu receptor induces a membrane depolarization, coupled with an increase of membrane resistance and of intracellular Ca2+ levels (Pisani et al., 2001b). The membrane depolarization is mediated by the closure of a K+ conductance (Takeshita et al., 1996; Calabresi et al., 1999; Bonsi et al., 2005) and leads to an increased release of ACh (Marti et al., 2001).