Elsevier

Neuropharmacology

Volume 40, Issue 3, March 2001, Pages 460-463
Neuropharmacology

Rapid communication
Functional coexpression of excitatory mGluR1 and mGluR5 on striatal cholinergic interneurons

https://doi.org/10.1016/S0028-3908(00)00184-2Get rights and content

Abstract

The group I mGluR agonist (S)-3,5-dihydroxyphenylglycine (3,5-DHPG) and the mGluR5 agonist 2-chloro-5-hydroxyphenylglycine both induced a membrane depolarisation of striatal cholinergic interneurons. The response to 3,5-DHPG was blocked only by the coadministration of mGluR1 and mGluR5 antagonists, suggesting that both mGluRs are involved in this excitatory effect in striatal cholinergic interneurons.

Section snippets

Acknowledgments

The technical help of Mr M. Tolu is gratefully acknowledged. This work was supported by Ministero Sanità (Finalizzato) and MURST (Cofinanziamento) grants to A.P. and G.B., respectively.

References (10)

There are more references available in the full text version of this article.

Cited by (49)

  • Pharmacology of metabotropic glutamate receptor allosteric modulators: Structural basis and therapeutic potential for CNS disorders

    2013, Progress in Molecular Biology and Translational Science
    Citation Excerpt :

    Therefore, alternative ways to modulate NMDA receptor activity have been sought. One possible target is mGlu5, which is a closely related signaling partner with NMDA receptors in brain regions involved in cognitive function and implicated in the pathology of schizophrenia such as the hippocampus, striatum, and prefrontal cortex.34,231,232,294–301 In addition, mGlu5 has also been shown to play a role in cognition.302,303

  • Distinct roles of group I mGlu receptors in striatal function

    2008, Neuropharmacology
    Citation Excerpt :

    Electrophysiological data are in support of a functional co-expression of both group I mGlu receptors. Indeed, in this neuronal subtype the activation of either group I mGlu receptor induces a membrane depolarization, coupled with an increase of membrane resistance and of intracellular Ca2+ levels (Pisani et al., 2001b). The membrane depolarization is mediated by the closure of a K+ conductance (Takeshita et al., 1996; Calabresi et al., 1999; Bonsi et al., 2005) and leads to an increased release of ACh (Marti et al., 2001).

View all citing articles on Scopus
View full text