Regulation of cardiac adrenomedullin-mRNA in different stages of experimental heart failure
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Adrenomedullin: Continuing to explore cardioprotection
2019, PeptidesCitation Excerpt :AM concentration decreased in the left atrium of renovascular hypertension [28] and in volume overloaded atria in rats [32], possibly due to the release from the intracellular stores of atrial cardiac myocytes. Atrial AM mRNA and concentration did not change in the failing hearts of rats, dogs, and humans, compared with that in the heart of controls [34,38,39]. The stimulatory G protein-adenylate cyclase-cAMP to activate protein kinase A is a major pathway that increases cardiac contractility [40].
Mechanisms regulating adrenomedullin gene expression in the left ventricle: Role of mechanical load
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