Induction of inducible nitric oxide synthase and heme oxygenase-1 in rat glial cells
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Manganese potentiates LPS-induced heme-oxygenase 1 in microglia but not dopaminergic cells: Role in controlling microglial hydrogen peroxide and inflammatory cytokine output
2011, NeuroToxicologyCitation Excerpt :Furthermore, a recent report demonstrated that high, cytotoxic concentrations of Mn (300 μM) induce HO-1 in PC12 cells via the Nrf2-ARE pathway (Li et al., 2010). The proinflammatory stimulus LPS, used to model PD, has also been linked to the induction of HO-1 in astrocytes and microglia (Kitamura et al., 1998). Pre-treatment with LPS resulted in a time dependent increase in HO-1 in microglia that increased anti-inflammatory activity following cytotoxic challenge (IFN-γ/LPS) (Lee and Suk, 2007).
Dipyridamole inhibits lipopolysaccharide-induced cyclooxygenase-2 and monocyte chemoattractant protein-1 via heme oxygenase-1-mediated reactive oxygen species reduction in rat mesangial cells
2011, European Journal of PharmacologyCitation Excerpt :It is possible that the high cellular cAMP and cGMP levels caused by the high dosage of dipyridamole will induce more serious inflammatory response in rat mesangial cells, and therefore reduce the anti-inflammatory effect of dipyridamole. Numerous studies showed that lipopolysaccharide induced the expression of HO-1 in many cell types (Camhi et al., 1995; Kitamura et al., 1998; Li et al., 2008). We found a low concentration (0.5 μg/ml) of lipopolysaccharide upregulated HO-1, but a high concentration (1 or 5 μg/ml) of lipopolysaccharide reduced the protein level of HO-1 in rat mesangial cells (Fig. 5A).
NO adsorption effects on various functional molecular nanowires
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