Pharmacology letter Accelerated communicationNaloxone inhibits the reinforcing and motivational aspects of cocaine addiction in mice
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Cited by (57)
Place preferences induced by electrical stimulation of the external lateral parabrachial subnucleus in a sequential learning task: Place preferences induced by NLPBe stimulation
2020, Behavioural Brain ResearchCitation Excerpt :In this way, the sequential procedure involves an acquisition phase with the simultaneous presentation of rewarding stimulus and associated maze compartment, followed by a delay before the learning of the animal is tested. It is well documented that the sequential procedure can be used to establish place preferences induced by the administration of natural rewards and especially drugs of abuse [25–37]. Thus, it has been widely reported that place preference conditioning is a highly sensitive tool to measure the rewarding properties of morphine [29,31,33,38–44].
The Nociceptin Receptor as an Emerging Molecular Target for Cocaine Addiction
2016, Progress in Molecular Biology and Translational ScienceEffects of saikosaponin A on cocaine self-administration in rats
2013, Neuroscience LettersCitation Excerpt :Endogenous opioid systems have been linked to the positive reinforcing properties of cocaine [14]. Pharmacological studies have shown that nonselective opioid antagonists attenuate cocaine self-administration [17,21] and cocaine-seeking behavior [4], indicating that endogenous opioid systems contribute to cocaine reward. This effect has been suggested to involve local disinhibition of dopamine neurons in the ventral tegmental area, causing the increase of dopamine release in the nucleus accumbens [13,15].
The endogenous opioid system: A common substrate in drug addiction
2010, Drug and Alcohol DependenceCitation Excerpt :In addition to the biochemical studies described above, there is a vast amount of pharmacological studies confirming the involvement of μ-, δ- and κ-opioid receptors in the rewarding effects of psychostimulants. Hence, the μ-preferring opioid antagonists naloxone and naltrexone attenuated cocaine-induced CPP in rodents (Bilsky et al., 1992; Gerrits et al., 1995; Houdi et al., 1989; Kim et al., 1997; Kuzmin et al., 1997a; Suzuki et al., 1992). Similarly, the selective μ-preferring opioid antagonists naloxonazine and CTAP also attenuated cocaine-induced CPP in rats (Rademacher and Steinpreis, 2002; Schroeder et al., 2007).
The opioid receptor antagonist naltrexone attenuates reinstatement of amphetamine drug-seeking in the rat
2009, Behavioural Brain Research