Original articlesCharacterization of ochratoxin A transport by human organic anion transporters
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Investigating the interaction between organic anion transporter 1 and ochratoxin A: An in silico structural study to depict early molecular events of substrate recruitment and the impact of single point mutations
2022, Toxicology LettersCitation Excerpt :The set of ligands included, along with OTA, 6-carboxyfluorescein, para-aminohippuric acid and prostaglandin E2 (Fig. 3). As reported in the USCD-FDA TransPortal database, all these ligands have been already described as high affinity substrates of OAT1 with Km values in the low μM range (Cihlar and Ho, 2000; Islinger et al., 2001; Jung et al., 2001; Kimura et al., 2002). The set of decoys was collected from the scientific literature and included homostachydrine, glycitein-7-glucuronide, pravastatin and beta-muricholate (Fig. 3) as previous studies ascertained that they are not appreciably transported or bound by OAT1 (Bush et al., 2017; Takeda et al., 2004; Wong et al., 2011).
A key role for the transporter OAT1 in systemic lipid metabolism
2021, Journal of Biological ChemistryMitigation of cell apoptosis induced by ochratoxin A (OTA) is possibly through organic cation transport 2 (OCT2) knockout
2018, Food and Chemical ToxicologyUptake Transporters
2018, Comprehensive Toxicology: Third Edition
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