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Effects of felbamate on veratridine- and K+-stimulated release of glutamate from mouse cortex

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Abstract

Felbamate is a novel anticonvulsant which may modulate the strychnine-insensitive glycine site of the N-methyl-d-aspartate (NMDA) receptor complex. This study examined the effect of felbamate and 5,7-dichlorokynurenic acid on veratridine (20 μM)- and K+ (60 mM)-stimulated release of amino acids in mouse cortical slices. Felbamate significantly decreased veratridine-induced release of glutamate at 400 μM and 800 μM but had no effect on K+-stimulated release. 5,7-Dichlorokynurenic acid had no effect on amino-acid release in concentrations up to 200 μM. The inhibitory effect of felbamate on veratridine-induced release of glutamate may be due to inactivation of voltage-sensitive Na+ channels.

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