Selegiline enhances NGF synthesis and protects central nervous system neurons from excitotoxic and ischemic damage
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2013, Medical HypothesesCitation Excerpt :Trophic factor withdrawal is a widely recognized cause of neuron apoptosis. It is therefore important to note that deprenyl, in addition to inhibiting apoptosis, may also exert protective effects on cones by the upregulation of eight neurotrophic factors: basic fibroblast growth factor, bFGF [28]; nerve growth factor, NGF [29]; ciliary neurotrophic factor, CNTF [30]; glial cell line-derived neutrophic factor, GDNF [31]; brain-derived neurotrophic factor and GDNF [32]; insulin-like growthfactor-1, IGF-1 [33]; superoxide dismutase via NGF [34]; and fibroblast growthfactor-2, FGF-2, and bFGF [35]. The delivery of one of these trophic factors, CNTF by Neurotech’s encapsulated cell technology, is currently undergoing clinical trials for RP and age-related macular degeneration [36].