Rapid communicationConstitutively active melatonin MT1 receptors in male rat caudal arteries
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Acknowledgments
This research was supported by grants USPHS RO1 MH 42922 (M.L.D.) and T32 AG00260 (Ç.E.).
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Melatonin Receptors as Modulators of Methamphetamine-Mediated Behaviors
2016, Neuropathology of Drug Addictions and Substance MisuseMelatonin Receptors as Modulators of Methamphetamine-Mediated Behaviors
2016, Neuropathology of Drug Addictions and Substance Misuse Volume 2: Stimulants, Club and Dissociative Drugs, Hallucinogens, Steroids, Inhalants and International AspectsGenetic deletion of the MT<inf>1</inf> or MT<inf>2</inf> melatonin receptors abrogates methamphetamine-induced reward in C3H/HeN mice
2014, Physiology and BehaviorCitation Excerpt :Genetic deletion of either the MT1 or MT2 melatonin receptors impaired the ability of METH to induce a place preference during the light phase, suggesting that the melatonin receptors may be activated during this period. Melatonin receptor activation, even when the levels of melatonin are low [10], could result from tight, irreversible binding of picomolar concentration of nocturnal endogenous melatonin to a population of receptors in a high affinity state [54,55] or by the presence of constitutively active receptors [56,57]. The lack of METH-induced CPP during the dark period when melatonin levels are high could be due to the presence of melatonin receptor desensitization [58,59].
Molecular pharmacology of the mouse melatonin receptors MT <inf>1</inf> and MT <inf>2</inf>
2012, European Journal of PharmacologyCitation Excerpt :We also lack knowledge about the functional couplings of these receptors. Recent evidence from our laboratory (Devavry et al., in press) seems to indicate that the melatonin receptors are constitutively active (Ersahin et al., 2002; Roka et al., 1999). Furthermore, the gold standard according to which melatonin receptors are mainly coupled to Gs seems also to be put in modern perspective, and checked systematically for other routes, in homodimers as well as in heterodimers involving at least one melatonin receptor subtypes (Ayoub et al., 2002; Jockers et al., 2008).
Characterization of two different melatonin binding sites in peripheral tissues of the teleost Tinca tinca
2012, General and Comparative EndocrinologyCitation Excerpt :In contrast to the large amount of available information on melatonin binding sites in vertebrate nervous system, a lack of knowledge exists regarding peripheral tissues, particularly in ectotherm animals. Early experiments localized saturable [125I]Mel binding sites in different mammalian peripheral tissues, such as the caudal artery [15], the uterus [49], and the gastrointestinal tract [35], among others. A low-affinity MT3 melatonin binding site was also localized and characterized in different tissues, such as the liver, hearth, kidney, lung, intestine, spleen and testis of different mammalian species [29].
Physiological effects of melatonin: Role of melatonin receptors and signal transduction pathways
2008, Progress in Neurobiology