Elsevier

Brain Research

Volume 789, Issue 1, 6 April 1998, Pages 171-174
Brain Research

Short communication
Naloxone does not alter amphetamine-induced rotational behavior or striatal dopamine levels of nigrally-lesioned rats

https://doi.org/10.1016/S0006-8993(98)00098-5Get rights and content

Abstract

Previous studies on rats have shown that the opioid antagonist naloxone attenuates amphetamine-induced stimulation of locomotor activity and increases in extracellular dopamine in the brain. However, in this study, naloxone did not attenuate amphetamine-induced rotational behavior or increases of extracellular dopamine in the intact striatum of nigrally-lesioned rats. These results suggest differences in the way in which endogenous opioids contribute to the behavioral and neurochemical effects of amphetamine in nigrally-lesioned compared to intact rats

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Acknowledgements

This research was supported by grant DA00541, Research Scientist Award K05 DA00008 (S.G.H), grants DA00541 and DA07532, Research Scientist Development Award K02 DA00179 (J.B.J.), and NRSA Predoctoral Fellowships F31 DA05692 (H.L.K.) and F31 DA05649 (C.A.S.), all from the National Institute on Drug Abuse, National Institutes of Health, and by grant IBN-9412703 from the National Science Foundation.

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