Elsevier

Brain Research

Volume 757, Issue 1, 16 May 1997, Pages 159-163
Brain Research

Short communication
Immunoreactivity of presenilin-1 in human, rat and mouse brain

https://doi.org/10.1016/S0006-8993(97)00243-6Get rights and content

Abstract

Monoclonal antibodies (mAbs) D3G6 and C8A5, specific for amino acid residues 160–168 of S182 protein, immunolabeled neurons, ependymal and choroid plexus cells, and myocytes in brain sections from normal subjects and people with Alzheimer disease or Down syndrome and in rats and mice. Oligodendroglia, microglia, and the majority of astrocytes were negative. S182 protein or a fragment of the protein detected with these mAbs is not a constituent of amyloid-β deposits or tangles.

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Acknowledgements

The authors thank to Ms. Maureen Stoddard Marlow for copy editing. Supported in part by funds from the New York State Office of Mental Retardation and a grant from the National Institutes of Health, National Institute of Aging No. PO1-AG11531.

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