Identification of a saturable uptake system for deoxyribonucleosides at the blood-brain and blood-cerebrospinal fluid barriers
References (74)
- et al.
Uptake of adenosine into cultured cerebral endothelium
Brain Res.
(1983) - et al.
Nucleoside transport in normal and neoplastic cells
Adv. Enzyme Regul.
(1993) - et al.
Independent blood-brain barrier transport systems for nucleic acid precursors
Biochim. Biophys. Acta
(1975) - et al.
Regional distribution of adenosine uptake in guinea-pig brain slices and the effect of some inhibitors: Evidence for nitrobenzylthioinosine-sensitive and insensitive sites?
Neurochem. Int.
(1986) Calculation of cerebral glucose phosphorylation from brain uptake of glucose analogues in vivo: a re-examination
Brain. Res.
(1982)- et al.
Nucleoside transport in brush-border membrane vesicles from human kidney
Biochim. Biophys. Acta
(1992) - et al.
Substrate selectivity, potential sensitivity and stoichiometry of Na+-nucleoside transport in brush-border membrane vesicles from human kidney
Biochim. Biophys. Acta
(1993) - et al.
Fluorocarbon perfusion of the isolated rat brain: Measurement of tissue spaces, EEG and oxygen uptake
Biochim. Biophys. Acta
(1991) - et al.
A morphometric study on the development of the lateral ventricle choroid plexus, choroid plexus capillaries and ventricular ependyma in the rat
Dev. Brain Res.
(1990) - et al.
Na+- and K+-dependent uridine transport in rat renal brush-border membrane vesicles
Biochim. Biophys. Acta
(1988)
Nucleoside and nucleobase transport in animal cells
Biochim. Biophys. Acta
Permeability of the developing blood-brain barrier tot4C-mannitol using the rat in situ brain perfusion technique
Dev. Brain Res.
Preservation of integrative function in a perfused guinea-pig brain
Brain. Res.
Kinetic analysis of [36Cl]-, [22Na]- and [3H]mannitol uptake into the in vivo choroid plexus-cerebrospinal fluid brain system: ontogeny of the blood-brain and blood-CSF barriers
Dev. Brain Res.
Thymidine accumulation by choroid plexus in vitro
Arch. Biochem. Biophys.
Nucleoside transport in choroid plexus: mechanism and specificity
Arch. Biochem. Biophys.
Uptake by central nervous tissues as a mechanism for the regulation of extracellular adenosine concentrations
Neurochem. Int.
Further characterization of the sodium-dependent nucleoside transporter (N3) in choroid plexus from rabbit
Biochim. Biophys. Acta
Sodium-dependent nucleoside transport in choroid plexus from rabbit
J. Biol. Chem.
Administration of 3′-azido-3′-deoxythymidine, an inhibitor of HTLV-III/LAV replication, to patients with AIDS or AIDS-related complex
Lancet
Kinetics of arginine-vasopressin uptake at the blood-brain barrier
Biochim. Biophys. Acta
Nucleoside uptake by slices of mouse brain
J. Neurochem.
Identification of hypoxanthine transport and xanthine oxidase activity in brain capillaries
J. Neurochem.
Intrathecal chemotherapy: Brain tissue profiles after ventriculo-cistemal perfusion
J. Pharmacol. Exp. Ther.
Brain microvessel endothelial cells in tissue culture: A model for study of blood-brain barrier permeability
Ann. Neurol.
The Concept of a Blood-Brain Barrier
The blood-brain barrier interface
Eye
Kinetics of regional blood-brain barrier glucose transport and cerebral blood flow determined with the carotid injection technique in conscious rats
J. Neurochem.
Distributed model for drug delivery to CSF and brain tissue
Am. J. Physiol.
Pyrimidine dideoxynucleosides: Selectivity of penetration into cerebrospinal fluid
J. Pharmacol. Exp. Ther.
Comparison of lipid-mediated blood-brain barrier penetrability in neonates and adults
Am. J. Physiol.
Efflux of radiolabelled polyethylene glycols and albumin from rat brain
Am. J. Physiol.
The Physiology of the CSF and Blood-Brain Barriers
The prevention of methotrexate toxicity by thymidine infusions in humans
Cancer Res.
Paper chromatography of several classes of compounds: CorrelatedRf values in a variety of solvent systems
Anal. Chem.
Pharmacological characterization of rapidly accumulated adenosine by dissociated brain cells from adult rat
J. Neurochem.
High and low- affinity transport ofd-glucose from blood to brain
J. Neurochem.
Cited by (35)
BrdU immunohistochemistry for studying adult neurogenesis: Paradigms, pitfalls, limitations, and validation
2007, Brain Research ReviewsCitation Excerpt :In vitro studies suggest that BrdU is transported by the same nucleoside transporter as thymidine (Lynch et al., 1977). Thymidine enters the brain primarily through facilitative low affinity, high-capacity carrier-mediated nucleoside transport system at the BBB, and may be eliminated through the cerebrospinal fluid, like thymidine (Thomas nee Williams and Segal, 1996; Thomas et al., 1997; Spector and Berlinger, 1982). It is estimated that BrdU is available for labeling in the adult brain for approximately a 2-h period, after systemic injection.
The characteristics of nucleobase transport and metabolism by the perfused sheep choroid plexus
2001, Brain ResearchCitation Excerpt :After the addition of 100 μM of unlabelled thymine to the perfusion medium HPLC analysis established that only thymine was present in the CSF at a concentration of 5.22±0.30 μM (n=4). The blood–brain barrier generally has a low permeability for nucleic acid precursors [4,2,35], an exception being for the nucleosides, adenosine [20] and thymidine in the guinea-pig [32,33]. It has also been shown that the transport capacity for purines at the blood–brain barrier is only sufficient to replace 2–3% of the total purines in the brain every 24 h [29].
Transporter-mediated permeation of drugs across the blood-brain barrier
2000, Journal of Pharmaceutical SciencesCitation Excerpt :Uridine distribution to brain is relatively low but saturable. However, a brain perfusion technique that is useful for slowly transported compounds at the BBB demonstrated a slow but saturable uptake of thymidine.69 Accordingly, it is suggested that both purine and pyrimidine nucleosides can be transported and purine nucleosides have higher permeability, presumably due to physiological need of a supply of purine nucleosides from blood circulation.72
Investigation of distribution, transport and uptake of anti-HIV drugs to the central nervous system
1999, Advanced Drug Delivery ReviewsDrug reformulation for a neglected disease. The nanohat project to develop a safer more effective sleeping sickness drug
2021, PLoS Neglected Tropical Diseases