Memantine induces heat shock protein HSP70 in the posterior cingulate cortex, retrosplenial cortex and dentate gyrus of rat brain
Reference (25)
Memantine is a potent blocker of N-methyl-d-aspartate (NMDA) receptor channels
Eur. J. Phamacol.
(1989)- et al.
Differential behavioral and neurochemical effects of competitive and noncompetitive NMDA receptor antagonists in rats
Eur. J. Pharrnacol.
(1992) - et al.
Memantine is highly potent in protecting cortical cultures against excitotoxic cell death evoked by glutamate and N-methyl-d-aspartate
Eur. J. Pharmacol.
(1991) - et al.
Memantine prevents quinolinic acid-induced hippocampal damage
Eur. J. Phamacol.
(1992) - et al.
Memantine displaces [3H]MK801 at therapeutic concentrations in postmortem human frontal cortex
Eur. J. Pharmacol.
(1989) - et al.
Patch clamp studies on the kinetic and selectivity of N-methyl-dh-aspartate receptor antagonism by memantine
Neuropharmacology
(1993) Therapeutic potential of excitatory amino acid antagonists: channel blockers and 2,3-benzodiazepines
Trends Pharmacol. Sci.
(1993)- et al.
Phencyclidine induction of the hsp70 gene in injured pyramidal neurons is mediated via multiple receptors and voltage gated calcium channels
Neuroscience
(1994) - et al.
Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist memantine
Brain Res.
(1996) - et al.
Amantadine induces c-fos in rat striatum: reversal with dopamine DI and NMDA receptor antagonists
Eur. J. Pharmacol.
(1995)
Open-channel block of N-methyl-d-aspartate responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity
J. Neurosci.
Induction of heat shock protein HSP70 in posterior cingulate and retrosplenial cortex of rat brain by dizocilpine and phencyclidine
Addiction Biol.
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A comparison of the pharmacokinetics and NMDAR antagonism-associated neurotoxicity of ketamine, (2R,6R)-hydroxynorketamine and MK-801
2021, Neurotoxicology and TeratologyCitation Excerpt :Another study reported that intraperitoneal doses of 100 mg/kg in female rats were necessary to induce HSP-70 formation, a biomarker for NMDAR antagonist neurotoxicity (Tian et al., 2018). In contrast, in male rats an intraperitoneal dose of 50 mg/kg was necessary to induce HSP-70 formation (Tomitaka et al., 1996). Given the observation by Olney that female rats were more susceptible to Olney lesion induction, the exact correlation between HSP-70 induction and Olney lesion formation remains of interest (Olney et al., 1989; Jevtovic-Todorovic et al., 2000).
Expression of heat shock protein HSP-70 in the retrosplenial cortex of rat brain after administration of (R,S)-ketamine and (S)-ketamine, but not (R)-ketamine
2018, Pharmacology Biochemistry and BehaviorCitation Excerpt :The order of potencies of neuropathological changes by the NMDAR antagonists in these regions is associated with the binding affinity of these compounds at NMDAR (Olney et al., 1989). Furthermore, the NMDAR antagonists, including (R,S)-ketamine, PCP and dizocilpine, were reported to cause heat shock protein HSP-70 (a marker of neuronal injury) in the same regions (Hashimoto et al., 1996, 1997; Nakki et al., 1996; Sharp et al., 1991, 1992; Tomitaka et al., 1996). Taken together, these findings raise the questions regarding the safety of (R,S)-ketamine in clinical and off-label use for mood disorders.
Neurorestorative effect of FTY720 in a rat model of Alzheimer's disease: Comparison with Memantine
2013, Behavioural Brain ResearchCitation Excerpt :Interestingly upon further experiments FTY720 seems to counteract NMDA-induced neuronal death in a BDNF-dependent manner [17]. Noncompetitive antagonists of NMDA receptor also augment the expression of several genes in limbic cortical [18,19] or hippocampal regions [20,21] which have been suggested partly underlie Memantine's therapeutic effects in AD patients. Accumulating evidence imply that Aβ aggregation could contribute to memory impairment especially through inducing transcripts of the genes involved in inflammatory or apoptotic pathways [22].
Emerging role of glutamate in the pathophysiology of major depressive disorder
2009, Brain Research ReviewsFluoxetine prevents PCP- and MK801-induced HSP70 expression in injured limbic cortical neurons of rats
2000, Biological Psychiatry