Short communicationOrexin neurons of the hypothalamus express adenosine A1 receptors
Section snippets
Acknowledgements
The Department of Veterans Affairs Medical Research Services (RWM), the National Institute of Mental Health Grants R37MH39683 (RWM) and KO1MH01798 (MMT) and the Sleep Medicine Education and Research Foundation (MMT) supported this work. We thank John Franco of the VAMC Animal Research Facility for providing care for the animals.
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2020, Behavioural Brain ResearchCitation Excerpt :In fact, the sleep-promoting effect of adenosine has been found to be mediated by inhibition of LH orexinergic neurons [138] (Fig. 4). Adenosine receptors are expressed on soma surface of orexin-releasing fibers in LH as well as the synaptic connections innervating these cells [139]. Cellular mechanisms through which adenosine suppresses orexin tone are thought to be the inhibition of action potentials generation, blocking of excitatory synaptic transmission and attenuation of calcium channels conductance [138].
Adenosine in the lateral hypothalamus/perifornical area does not participate on the CO<inf>2</inf> chemoreflex
2020, Respiratory Physiology and NeurobiologyCitation Excerpt :However, whether ADO signaling in the LH/PFA also affects the hypercapnic ventilatory response has not been determined. Adenosine A1 receptors are widely expressed in the region of LH/PFA and the presence of these receptors specifically in the orexinergic neurons has been described (Thakkar et al., 2002). On the other hand, the presence of adenosine A2 and A3 receptors has not been well characterized in this region (Dunwiddie and Masino, 2001).
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2019, Handbook of Behavioral NeuroscienceAdenosine has two faces: Regionally dichotomous adenosine tone in a model of epilepsy with comorbid sleep disorders
2018, Neurobiology of DiseaseRole of orexin type-1 receptors in paragiganto-coerulear modulation of opioid withdrawal and tolerance: A site specific focus
2017, NeuropharmacologyCitation Excerpt :Another regulatory mechanism affecting the role of OX1Rs in expression of opiate withdrawal is the involvement of adenosine receptors. It has been reported that adenosine type-1 (A1) receptors are expressed on cell bodies of hypothalamic orexinergic neurons as well as the presynaptic terminals innervating these cells (Thakkar et al., 2002). Adenosine has been shown to suppress the activity of orexin neurons by depressing the generation of action potentials, blocking excitatory synaptic transmission and attenuation of calcium currents.