Elsevier

Brain Research

Volume 881, Issue 2, 27 October 2000, Pages 212-216
Brain Research

Short communication
Na+–Ca2+ exchanger isoforms in rat neuronal preparations: different changes in their expression during postnatal development

https://doi.org/10.1016/S0006-8993(00)02808-0Get rights and content

Abstract

We examined the relative amounts of Na+–Ca2+ exchanger (NCX) isoform mRNAs in cultured neurons, astrocytes and developmental rat brain. NCX1 transcript was predominant in neurons and astrocytes, but NCX2 transcript was about four-fold higher than NCX1 or NCX3 transcript in adult rat cortex. NCX2 transcript in the cortex increased markedly during postnatal development, whereas NCX1 and NCX3 transcripts decreased. Na+-dependent 45Ca2+ uptake in the cortical homogenate increased significantly during postnatal development.

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Acknowledgements

This work was supported by grants form the Ministry of Education, Science, Sports, and Culture of Japan and Taisho Pharmaceutical Co., Ltd.

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