Research paperImpairment of phosphatidylinositol signaling in acetylshikonin-treated neutrophils☆
References (31)
- et al.
Regulation of inositol phospholipidspecific phospholipase C isozymes
J Biol Chem
(1992) - et al.
Inhibition of hind-paw edema and cutaneous vascular plasma extravasation in mice by acetylshikonin
Eur J Pharmacol
(1995) - et al.
Daphnoretin-induced respiratory burst in rat neutrophils is, probably, mainly through protein kinase C activation
Eur J Pharmacol
(1995) - et al.
A new generation of Ca2+ indicators with greatly improved fluorescence properties
j Biol Chem
(1985) - et al.
Cyclopiazonic acid depletes intracellular Ca2+ stores and activates an influx pathway for divalent cations in HL-60 cells
J Biol Chem
(1992) - et al.
Ca2+ influx following receptor activation
Trends Pharmacol Sci
(1991) - et al.
Cyclopiazonic acid is a specific inhibitor of the Ca2+-ATPase of sarcoplasmic reticulum
J Biol Chem
(1989) - et al.
Activation of calcium entry by the tumor promoter thapsigargin in parotid acinar cells: Evidence that an intracellular calcium pool, and not an inositol phosphate, regulates calcium fluxes at the plasma membrane
J Biol Chem
(1989) - et al.
A soluble cellular factor directly stimulates Ca2+ entry in neutrophils
Biochem Biophys Res Commun
(1995) - et al.
Role of phosphoinositides in transmembrane signaling
Physiol Rev
(1990)
Inositol phosphate biochemistry
Annu Rev Biochem
Studies and perspectives of protein kinase C
Science
Inositol phosphates and cell signalling
Nature
Pharmacological studies on crude plant drugs, Shikon and Tooki. (II) Shikonin and acetylshikonin
Nippon Yakurigaku Zasshi
Antitumor activity of shikonin and its derivatives
Chem Pharm Bull (Tokyo)
Cited by (22)
Immunogenetic disorders: Treatment with phytomedicines
2022, Immunogenetics: a Molecular and Clinical Overview: Clinical Applications of Immunogenetics, Volume IISelf-reporter shikonin-Act-loaded solid lipid nanoparticle: Formulation, physicochemical characterization and geno/cytotoxicity evaluation
2014, European Journal of Pharmaceutical SciencesCitation Excerpt :Shikonin is well known for a wide spectrum of bioactivities, including anti-inflammatory (Andujar et al., 2012; Liang et al., 2013; Xiong et al., 2013), anti-HIV (Chen et al., 2001, 2003), anti-bacterial (Shen et al., 2002), anti-oxidant (Han et al., 2008), anti-inflammatory (Singh et al., 2003) and anti-tumor. While, during previous non-comprehensive investigation, shikonin-Act showed some bioactivities including: adipogenesis inhibiting (Gwon et al., 2012) through inhibition of 5-lipoxygenase activity (Hsu et al., 2009), inhibition of the generation of NADPH oxidase complex (Kawakami et al., 1996) and inhibition of phosphatidylinositol signaling pathway (Wang and Kuo, 1997). Shikonin and shikonin-Act represents potent inhibiting effects against diverse tumors via special molecular pathways.
Separation methods of quinonoid constituents of plants used in Oriental traditional medicines
2004, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life SciencesSuppression of receptor-mediated Ca<sup>2+</sup> mobilization and functional leukocyte responses by hyperforin
2004, Biochemical PharmacologyShikonins, Phytocompounds from Lithospermum erythrorhizon, Inhibit the Transcriptional Activation of Human Tumor Necrosis Factor α Promoter in Vivo
2004, Journal of Biological Chemistry
- ☆
This work was supported by a grant from the National Science Council of the Republic of China (NSC83-0420-B-075A-021 M03).