Research paperIdentification of c-Src as the integral component of the cytosolic Ah receptor complex, transducing the signal of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) through the protein phosphorylation pathway☆
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2020, Environmental ResearchCitation Excerpt :In general, the detoxification metabolism process of xenobiotic substance involves AhR signaling pathway, Phase I, II and III detoxification metabolism system. Normally, AhR is a ligand-activated transcriptional factor, composing unactivated multiprotein complex with HSP90, XAP2 and p23 proteins in cells (Hoffman et al., 1991; Enan and Matsumura, 1996; Kazlauskas et al., 2001). Once the exogenous contaminant ligand binds to AhR, the AhR conformation would change and translocate into the nucleus, dimerizating with ARNT, then combine with XRE and regulate the expression of response genes including CYP1A1, CYP1B1, GST, and ABC efflux transporters (Rowlands and Gustafsson, 1997; Saarikoski et al., 2005; Bock and Köhle, 2006; Guo et al., 2017).
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This work was supported by ES03575, ES05233, and ES05707 from the National Institute of Environmental Health Sciences, Research Triangle Park, NC.