Cardiovascular Effects of Protamine Sulfate
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Circulation
Cited by (66)
Charge is an important determinant of hemodynamic and adverse cardiovascular effects of cationic drugs
2015, Pharmacological ResearchCitation Excerpt :Primarily, the compounds with greater cationic charge (e.g., HMW-PLL and hexadimethrine) produced a transient suppression of the P-wave size after each dose administered. However, all were devoid of effect on the PR interval or QRS width of the ECG, an effect similar to that observed by Goldman et al. [50] for protamine and Kimura et al. [37] for hexadimethrine. The effect is only transient in nature which likely relates to the tight binding of the cationic compound to vascular endothelial glycosaminoglycans, rapid accumulation within the luminal layer of the vessel wall and rapid hepatic clearance mechanisms [10,39].
Protamine
2007, xPharm: The Comprehensive Pharmacology ReferenceEffects of a thromboxane receptor antagonist (NT-126) and a thromboxane synthase inhibitor (OKY-046) on protamine-induced circulatory changes in dogs
2000, Journal of Cardiothoracic and Vascular AnesthesiaCitation Excerpt :It appears that acute responses to protamine administration differ between humans and animals. In animals, previous studies19-21 showed that pulmonary hypertension resulting from pulmonary vasoconstriction after protamine is relatively common, as in the present study, in which the overall incidence was 25%. In contrast, the incidences of pulmonary hypertension attributable to protamine reversal of heparin in humans have been reported to be 1% to 3%.22-24
Low-dose protamine based on heparin-protamine titration method reduces platelet dysfunction after cardiopulmonary bypass
1999, Journal of Thoracic and Cardiovascular Surgery
Supported in part by U.S. Public Health Servicegrants HE-06664 (HEPP) and HE-08043.