Cardiovascular Effects of Protamine Sulfate

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References (22)

  • R.L. Berger et al.

    Reduced protamine dosage for heparin neutralization in open-heart operations

    Circulation

    (1968)
  • Cited by (66)

    • Charge is an important determinant of hemodynamic and adverse cardiovascular effects of cationic drugs

      2015, Pharmacological Research
      Citation Excerpt :

      Primarily, the compounds with greater cationic charge (e.g., HMW-PLL and hexadimethrine) produced a transient suppression of the P-wave size after each dose administered. However, all were devoid of effect on the PR interval or QRS width of the ECG, an effect similar to that observed by Goldman et al. [50] for protamine and Kimura et al. [37] for hexadimethrine. The effect is only transient in nature which likely relates to the tight binding of the cationic compound to vascular endothelial glycosaminoglycans, rapid accumulation within the luminal layer of the vessel wall and rapid hepatic clearance mechanisms [10,39].

    • Protamine

      2007, xPharm: The Comprehensive Pharmacology Reference
    • Effects of a thromboxane receptor antagonist (NT-126) and a thromboxane synthase inhibitor (OKY-046) on protamine-induced circulatory changes in dogs

      2000, Journal of Cardiothoracic and Vascular Anesthesia
      Citation Excerpt :

      It appears that acute responses to protamine administration differ between humans and animals. In animals, previous studies19-21 showed that pulmonary hypertension resulting from pulmonary vasoconstriction after protamine is relatively common, as in the present study, in which the overall incidence was 25%. In contrast, the incidences of pulmonary hypertension attributable to protamine reversal of heparin in humans have been reported to be 1% to 3%.22-24

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    Supported in part by U.S. Public Health Servicegrants HE-06664 (HEPP) and HE-08043.

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