Pharmacodynamic profile of prostacyclin
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2023, Journal of Traditional and Complementary MedicineCitation Excerpt :In addition to NO, a prostanoid, PGI2, is an important vasodilator derived from the endothelium, synthesized from arachidonic acid by enzymatic reaction of the cyclooxygenease (COX) pathway. PGI2 induces vascular smooth muscle relaxation by stimulating the adenylate cyclase to produce cyclic AMP that leads to a decrease in intracellular Ca2+, which, in turn, induces relaxation of vascular smooth muscle.24,25 The present finding shows that the vasorelaxing effect of G. cowa leaf extract was reduced when the thoracic aortic rings were pre-incubated with COX inhibitor indomethacin, suggesting that G. cowa leaf extract can stimulate prostanoid production and subsequently induce vasorelaxation.
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2023, ChestCitation Excerpt :Although there is an advancing appreciation that PAH is a heterogeneous disease with clinical differences within subgroups, still missing is a comprehensive catalogue of molecular and metabolic profiles underlying the clinical manifestations of PAH subgroup. Namely, plasma metabolomic profiles have been reported in PAH,29-32 and a few reports have examined circulating metabolites that may point to potential metabolic pathways altered in SSc (with or without PAH).33,34 These studies indicated that distinct metabolic signatures exist between PAH and healthy or disease control subjects.
Successful use of inhaled epoprostenol as rescue therapy for pediatric ARDS
2020, Respiratory Medicine Case ReportsCitation Excerpt :Prostacyclin is a naturally occurring prostaglandin which exerts its effects on vascular smooth muscle through a mechanism of action that is uniquely different from INO, and this probably accounts for its additional benefits in various pathologic conditions. It increases the concentration of cyclic adenosine monophosphate in vascular smooth muscle cells while INO produces cyclic guanosine monophosphate [18]. Prostacyclin also increases endogenous surfactant production, which is beneficial in ARDS because it may decrease the need for toxic ventilator settings by improving lung compliance [10].
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