In situ hybridization and immunohistochemical localization of heme oxygenase-2 mRNA and protein in normal rat brain: Differential distribution of isozyme 1 and 2
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Upregulation of hemeoxygenase enzymes HO-1 and HO-2 following ischemia-reperfusion injury in connection with experimental cardiac arrest and cardiopulmonary resuscitation: Neuroprotective effects of methylene blue
2021, Progress in Brain ResearchCitation Excerpt :For HO-2 ELISA Kit (#MBS2506874; My BioSource, San Diego, CA, USA) was used. The ELISA kit sensitivity of HO-1 was 0.937 ng/mL to 60 ng/mL and HO-2 detection range was 0.375 ng/mL to 40 ng/mL (Ewing and Maines, 1992; Kitchin et al., 2001). Small tissue pieces of porcine brain from cerebral cortex, hippocampus and cerebellum were dissected immediately after removal and weighed immediately on a preweighed filter paper on an electronic analytical balance (sensitivity 0.1 mg; Mettler Toledo AB, Stockholm, Sweden).
Characterization of heme oxygenase and biliverdin reductase gene expression in zebrafish (Danio rerio): Basal expression and response to pro-oxidant exposures
2016, Toxicology and Applied PharmacologyBidirectional neuro-glial signaling modalities in the hypothalamus: Role in neurohumoral regulation
2013, Autonomic Neuroscience: Basic and ClinicalHeme oxygenase-1 and chronic hypoxia
2012, Respiratory Physiology and NeurobiologyCitation Excerpt :HO-1, an inducible isoform of the enzyme, has been shown to increase under various conditions including heat shock or oxidative stress. HO-2 is found in discrete neuronal populations throughout the brain closely paralleling the distribution of guanylyl cyclase (Ewing and Maines, 1992; Maines et al., 1993; Mazza et al., 2001; Verma et al., 1993) as well as in peripheral autonomic ganglia including the petrosal, superior cervical, nodose and myenteric ganglia (Zakhary et al., 1996). A role for HO mediated production of CO has been proposed to be important for many brain processes (for a review see Ryter et al., 2006).