Trends in Biochemical Sciences
ReviewHaem as a multifunctional regulator
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Low-dose carbon monoxide suppresses metastatic progression of disseminated cancer cells
2022, Cancer LettersCitation Excerpt :We investigated how blocking heme levels could slow metastatic cancer progression. Heme is known to stimulate the production of many hemoproteins [50,51]; therefore, we searched for hemoproteins whose expression was downregulated by low-dose CO and found that mRNA and protein levels of CYP1B1 were significantly reduced by 250 ppm CO in both MCF7 and MDA-MB-231 cells (Fig. 6A and B). The cytochrome P450 1 (CYP1) family consists of three genes (CYP1A1, CYP1A2, and CYP1B1) in humans.
Effect of cigarette smoke extract on mitochondrial heme-metabolism: An in vitro model of oral cancer progression
2019, Toxicology in VitroCitation Excerpt :As known, heme- or iron-protoporphyrin IX, is an essential byproduct of mitochondrial heme-metabolic pathway. Heme helps in transportation and storage of oxygen and involves in oxygen metabolism as well as control oxidative damage (Mense and Zhang, 2006; Padmanaban et al., 1989) during many fundamental processes of the cells. It has crucial role in enhancing cellular proliferation, migration and colony formation in many cancer types (Hooda et al., 2013), including oral cancer.
Tat-biliverdin reductase A inhibits inflammatory response by regulation of MAPK and NF-κB pathways in Raw 264.7 cells and edema mouse model
2015, Molecular ImmunologyCitation Excerpt :The antioxidant effects of HO are functioned together with bilirubin, which is known as a strong antioxidant. Biliverdin reductase A (BLVRA) converts biliverdin to bilirubin (Padmanaban et al., 1989; Maines, 1997; Siow et al., 1999). Strong antioxidant protection by BLVRA is induced if the physiological concentration of bilirubin is low activating the bilirubin/biliverdin cycle (Baranano et al., 2002; Sedlak and Snyder, 2004; Vitek and Schwertner, 2007; Jansen and Daiber, 2012).
Changes in heme oxygenase level during development affect the adult life of Drosophila melanogaster
2023, Frontiers in Cellular NeuroscienceA pseudokinase version of the histidine kinase ChrS promotes high heme tolerance of Corynebacterium glutamicum
2022, Frontiers in Microbiology