Trends in Biochemical Sciences
Reflections on biochemistryOn the discovery of glutathione
References (45)
- et al.
J. Biol. Chem.
(1927) - et al.
J. Biol. Chem.
(1927) J. Biol. Chem.
(1927)J. Biol. Chem.
(1929)- et al.
J. Biol. Chem.
(1929) - et al.
J. Biol. Chem.
(1930) - et al.
J. Biol. Chem.
(1930) J. Biol. Chem.
(1930)- et al.
J. Biol. Chem.
(1934) - et al.
J. Biol. Chem.
(1929)
J. Biol. Chem.
C. R. Acad. Sci.
Biochem. J.
C. R. Acad. Sci.
Bull. Soc. Hist. Nat. Toulouse
C. R. Seances Acad. Sci.
Bull. Soc. Hist. Nat. Toulouse
Bull. Soc. Hist. Nat. Toulouse
Bull. Soc. Hist. Nat. Toulouse
C. R. Sess./Assoc. F. Av. Sci. Pt.
C. R. Seances Mem. Soc. Biol.
C. R. Seances Mem. Soc. Biol.
Cited by (95)
Thiol sensing: From current methods to nanoscale contribution
2022, Microchemical JournalCitation Excerpt :GSH is involved in regulating pathways, protection against radical damages [12,13], signal transduction [14], cell cycle [15] …. GSH concentrations range from 100 µM to 10 mM and from 0.6 µM to 100.0 µM in blood and plasma respectively [16]. GSH is tightly linked to GSSG and their balance gives information about the cell oxidative stress state [17] among other indications.
Glutathione and glutathione-dependent enzymes
2022, Redox Chemistry and Biology of ThiolsUnique thiol metabolism in trypanosomatids: Redox homeostasis and drug resistance
2022, Advances in ParasitologyCitation Excerpt :Although, the general organization and relevance of the pentose phosphate pathways are similar in trypanosomatids and mammals; some of the enzymes present marked differences, either in the structure or the kinetics, or both, which make them suitable candidates as drug targets for specific chemotherapy. Glutathione (GSH), a tripeptide, γ-L-glutamyl-L-cysteinyl-glycine, represents the most ubiquitous low molecular mass thiol in mammalian cells (Meister, 1988). GSH can non-enzymatically scavenge many free radicals, like hydroxyl (•OH), superoxide (O2•−), peroxynitrite (ONOO −), and lipid peroxyl radical.
Role of protein S-Glutathionylation in cancer progression and development of resistance to anti-cancer drugs
2021, Archives of Biochemistry and BiophysicsCitation Excerpt :It is the most abundant thiol in eukaryotic cells with concentrations ranging from 1 to 10 mM [3,4]. The majority of GSH is present in the cytoplasm (up to 90%), where it is synthesized, but significant amounts are also found in the mitochondria and the endoplasmic reticulum, while the nucleus holds a small fraction [2]. Although glutathione is best known for its antioxidant [2,5–7] and detoxification functions [8], its other properties are slowly coming to the fore [9–13].
One-step preparation of hydrophilic metal-organic framework materials with bimetallic linkers and polycarboxylic acid ligands and their adsorption properties
2021, Colloids and Surfaces A: Physicochemical and Engineering Aspects