Non thiazolidinedione antihyperglycaemic agents. 2: α-Carbon substituted β-phenylpropanoic acids1

doi:10.1016/0960-894X(96)00382-4

Bioorganic & Medicinal Chemistry Letters

Volume 6, Issue 17, 3 September 1996, Pages 2127-2130

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Abstract

The thiazolidine-2,4-dione ring of insulin sensitising antidiabetic agents can be replaced by α-acyl-, α-alkyl- and α-(aralkyl)-carboxylic acids. Inclusion of an additional lipophilic moiety affords compounds 14 and 16, equipotent to BRL 48482.

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Non thiazolidinedione antihyperglycaemic agents. 2: α-Carbon substituted β-phenylpropanoic acids1

Abstract

J. Biol. Chem.

Cell

J. Med. Chem.

Non thiazolidinedione antihyperglycaemic agents. 2: α-Carbon substituted β-phenylpropanoic acids¹