Protein tyrosine kinases in the initiation of antigen receptor signaling
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A multiplex human syndrome implicates a key role for intestinal cell kinase in development of central nervous, skeletal, and endocrine systems
2008, American Journal of Human GeneticsCitation Excerpt :Kinases are particularly important for signal transduction and coordination of complex cellular functions, as seen with the mitogen-activated protein (MAP) kinases and cyclin-dependent kinases (CDKs), which play a central role in regulating mammalian cell proliferation and division.2 Altered kinase activity or abnormal substrate phosphorylation has been implicated in monogenic diseases—“kinasopathies”—including endocrine disorders,3 cancers,4 immunodeficiencies,5 and cardiovascular diseases.6 Inherited skeletal dysplasias or osteochondrodysplasias are characterized by abnormal development, growth, and maintenance of the skeleton.7
Expression profile of protein tyrosine kinase genes in human osteoarthritis chondrocytes
2001, Osteoarthritis and CartilageEffects of hemizygous CD45 expression in the autoimmune Fasl<sup>gld/gld</sup>syndrome
2001, Cellular ImmunologySignal transduction by the high-affinity immunoglobulin E receptor FcεRI: Coupling form to function
2001, Advances in ImmunologyCitation Excerpt :The FcεRI receptor does not contain intrinsic catalytic activity. Instead, it associates with nontransmembrane protein tyrosine kinases (PTKs) that phosphorylate tyrosine residues found in the ITAMs of β- and γ-chains (Bolen, 1995; Daeron et al., 1995; Paolini et al., 1991). The ITAM is present in both the β- and γ-chains and is centrally important to signal initiation (Fig. 1).
Mechanistic aspects of the induction of apoptosis by Lauryl Gallate in the murine B-cell lymphoma line Wehi 231
2000, Archives of Biochemistry and Biophysics