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Some unusual effects of α2-adrenergic drugs on cortical high voltage spindles in rats

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Abstract

The dose-response curves for a number of α-adrenergic drugs were investigated to estimate a possible role of the α2/α1 selectivity of these drugs on the incidence of cortical high voltage spindles (HVS), reflecting level of vigilance. The α2 antagonists yohimbine (0.25–4 mg/kg) and idazoxan (0.5–4 mg/kg), but not atipamezole induced a biphasic effect on the incidence of HVS in rats. This effect of relatively small doses of yohimbine and idazoxan should be taken into consideration when using these drugs as ga2 antagonists in behavioral and neurophysiological tests. On the other hand the linearity of the dose-response curve for atipamezole (0.01–4 mg/kg) indicates that this drug is a good candidate for use in such tests.

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