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Spermine reciprocally changes the affinity of NMDA receptor agonists and antagonists

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    The binding of noncompetitive antagonists to the PCP site can be potentiated by polyamines that bind at a further recognition site: the polyamine site (MacDonald & Nowak, 1990; Lodge & Johnson, 1990). Polyamines (e.g., spermine) also enhance the binding of competitive antagonists to the NMDA recognition site, but decrease NMDA-sensitive glutamate binding (Pullman & Powel, 1991). Magnesium probably acts as an open-channel blocker by binding to a site deeper within the channel, but there is also an inhibitory divalent cation site thought to be located outside the channel lumen (Barnes & Henley, 1992).

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