European Journal of Pharmacology: Molecular Pharmacology
Volume 207, Issue 2, 19 June 1991, Pages 173-174
Rapid communicationSpermine reciprocally changes the affinity of NMDA receptor agonists and antagonists
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2000, Pharmacology and TherapeuticsCitation Excerpt :The binding of noncompetitive antagonists to the PCP site can be potentiated by polyamines that bind at a further recognition site: the polyamine site (MacDonald & Nowak, 1990; Lodge & Johnson, 1990). Polyamines (e.g., spermine) also enhance the binding of competitive antagonists to the NMDA recognition site, but decrease NMDA-sensitive glutamate binding (Pullman & Powel, 1991). Magnesium probably acts as an open-channel blocker by binding to a site deeper within the channel, but there is also an inhibitory divalent cation site thought to be located outside the channel lumen (Barnes & Henley, 1992).
Allosteric modulation of the glutamate site on the NMDA receptor by four novel glycine site antagonists
1995, European Journal of Pharmacology: Molecular PharmacologyPolyamine potentiation and inhibition of NMDA-mediated increases of intracellular free Ca<sup>2+</sup> in cultured chick cortical neurons
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Copyright © 1991 Published by Elsevier B.V.