Research paperOlanzapine and fluperlapine mimic clozapine in preventing MK-801 neurotoxicity
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Metformin reverses the schizophrenia-like behaviors induced by MK-801 in rats
2019, Brain ResearchCitation Excerpt :Thus, we chose the method of chronic treatment with MK-801 in our model of schizophrenia. Olanzapine (OLZ) has been shown to have a protective effect against the neurotoxicity of MK-801 better then fluperlapine, clozapine, loxapine, and amoxapine in rats (Farber et al., 1996). In addition, it has been documented that the use of second-generation antipsychotics reverses MK-801-induced cognitive deficits better than first-generation antipsychotics (Liu et al., 2017b).
Management of psychiatric symptoms in anti-NMDAR encephalitis: A case series, literature review and future directions
2014, General Hospital PsychiatryCitation Excerpt :Also, neuroleptic malignant syndrome (NMS) and anti-NMDAR encephalitis have overlapping symptoms including altered mental status, fever, abnormal movements and autonomic disturbances which can result in a delay of diagnosis of anti-NMDAR encephalitis [12]. Clozapine and structurally similar antipsychotics (olanzapine, loxapine and amoxapine) have been shown to prevent NMDA receptor antagonist toxicity [30], but the phlebotomy requirements of clozapine might make it difficult to administer. Other antipsychotics that have been used include chlorpromazine, aripiprazole, risperidone and ziprasidone [1,14].
5-HT<inf>2A</inf> serotonin receptor agonist DOI alleviates cytotoxicity in neuroblastoma cells: Role of the ERK pathway
2013, Progress in Neuro-Psychopharmacology and Biological PsychiatryTracing the development of psychosis and its prevention: What can be learned from animal models
2012, NeuropharmacologyCitation Excerpt :The mechanisms underlying the efficacy of the two APDs to arrest the development of structural brain abnormalities in poly I:C offspring remain to be investigated but some speculations may be offered. There is increasing in vitro and in vivo evidence that atypical APDs exert wide-ranging neuroprotective effects on the brain, including protection against excitotoxicity and oxidative stress, blockade or reversal of neurodegenerative processes associated with apoptosis and oxidative stress, enhancement of neural cell functions, resilience and plasticity, and promotion of neurogenesis, connectivity, and neuronal survival (Bai et al., 2003; Farber et al., 1996; Halim et al., 2004; Jarskog et al., 2007; Keilhoff et al., 2010; Wakade et al., 2002) (for review see Lieberman et al., 2008). Thus, the preventive actions of APDs could at least in part stem from their neuroprotective effects.
Neuropeptide S attenuates neuropathological, neurochemical and behavioral changes induced by the NMDA receptor antagonist MK-801
2010, NeuropharmacologyCitation Excerpt :NPS also significantly improved MK-801-induced PPI deficits in mice. It has been reported that clozapine can attenuate neuropathological changes (Farber et al., 1996; Hashimoto et al., 2000) as well as PPI deficits (Bakshi et al., 1994; Geyer and Ellenbroek, 2003) produced by administration of MK-801. Our present data demonstrate that in these paradigms NPS shows a pharmacological profile similar to that of clozapine.
Effects of acute and chronic administration of MK-801 on c-Fos protein expression in mice brain regions implicated in schizophrenia with or without clozapine
2009, Progress in Neuro-Psychopharmacology and Biological Psychiatry