Elsevier

Schizophrenia Research

Volume 21, Issue 1, 31 July 1996, Pages 33-37
Schizophrenia Research

Research paper
Olanzapine and fluperlapine mimic clozapine in preventing MK-801 neurotoxicity

https://doi.org/10.1016/0920-9964(96)00024-2Get rights and content

Abstract

Antagonists of the N-methyl-d-Aspartate (NMDA) subtype of glutamate receptor (e.g., phencyclidine, ketamine, MK-801) cause a schizophrenia-like psychosis in humans and neurotoxicity in the adult rat brain. We report here that clozapine and structurally related agents (olanzapine, fluperlapine, loxapine, amoxapine) can prevent NMDA antagonist neurotoxicity in the rat with a rank order corresponding to their ability to mimic the antipsychotic properties of clozapine.

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