Neuron
ArticleA post-docking role for synaptobrevin in synaptic vesicle fusion
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Fast, Ca<sup>2+</sup>-dependent exocytosis at nerve terminals: Shortcomings of SNARE-based models
2014, Progress in NeurobiologyCitation Excerpt :Thus, additional work will be needed to clarify the importance of syntaxin 1a for the function of vertebrate synapses. Among the seminal studies of SNARE function at the synapse, Hunt et al. (1994) monitored the impact on evoked transmitter release of presynaptic introduction of clostridial neurotoxins known to target synaptobrevin. The toxins caused a slow blockade of evoked transmitter release at the squid giant synapse that was largely complete after 2–3 h (similar results were seen at Aplysia synapses; Schiavo et al., 1992).
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2014, From Molecules to Networks: An Introduction to Cellular and Molecular Neuroscience: Third EditionDocking and fusion of synaptic vesicles in cell-free model system of exocytosis
2008, Neurochemistry InternationalMolecular form follows function: (un)snaring the SNAREs
2008, Trends in NeurosciencesCoats, Tethers, Rabs, and SNAREs Work Together to Mediate the Intracellular Destination of a Transport Vesicle
2007, Developmental CellCitation Excerpt :Thus, the mere presence of a SNARE cannot be the sole determinant of the direction in which a vesicle is traveling. Furthermore, the interactions of SNAREs are promiscuous (Tsui and Banfield, 2000; von Mollard et al., 1997), and the disruption of SNARE complex formation does not block vesicle tethering (Broadie et al., 1995; Hunt et al., 1994). These findings indicate that SNAREs do not mediate the first point of contact between a vesicle and its target.
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The first two authors contributed equally to this paper.
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Present address: Max Delbrück Center for Molecular Medicine Berlin, Federal Republic of Germany.