Neuron
ArticleCloning of a novel glutamate receptor subunit, GluR5: Expression in the nervous system during development
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2023, Advances in NeurotoxicologyAntagonism of GluK1-containing kainate receptors reduces ethanol consumption by modulating ethanol reward and withdrawal
2021, NeuropharmacologyCitation Excerpt :Thus, selective inhibition of GluK1*KARs could be efficacious in decreasing drinking with fewer adverse effects than TPM. The GluK1 subunit is expressed throughout the brain, including in regions that modulate different aspects of addiction, such as anterior cingulate cortex (Wu et al., 2007), hippocampus (Christensen et al., 2004; Clarke and Collingridge, 2004), ventral pallidum (Bischoff et al., 1997; Wisden and Seeburg, 1993), basolateral amygdala (BLA) (Wu et al., 2007), and cortical afferents projecting to the nucleus accumbens (NAc) (Bettler et al., 1990; Casassus and Mulle, 2002). Hence, GluK1*KARs could modulate various aspects of alcohol dependence, such as positive reinforcement, withdrawal, and alcohol-seeking behaviors.
Losing balance: Kainate receptors and psychiatric disorders comorbidities
2021, NeuropharmacologyA comparative analysis of kainate receptor GluK2 and GluK5 knockout mice in a pure genetic background
2021, Behavioural Brain ResearchCitation Excerpt :KARs are tetrameric channels assembled from a combination of low-affinity kainate GluK1-GluK3 (GluR5-GluR7) and high-affinity kainate GluK4-GluK5 (KA1-KA2) subunits, which exhibit significant differences in terms of their spatiotemporal expression patterns in the brain [17]. Low-affinity subunits form functional homomeric KARs [18,19], while high-affinity subunits require any of the low-affinity subunits to generate functional KARs [20]. Among the various heteromeric subunit combinations, GluK2/GluK5 KARs are known to be the most abundant KARs in the brain [17,21].
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Present address: Center for Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106.