ArticleBehavioral and neurochemical effects of chronic methylenedioxymethamphetamine (MDMA) treatment in rhesus monkeys
References (35)
- et al.
Oral administration of 3,4-Methylenedioxymethamphetamine (MDMA) produces selective serotonergic depletions in the nonhuman primate
Neurotoxicol. Teratol.
(1993) - et al.
MDMA-induced neurotoxicity: Parameters of degeneration and recovery of brain serotonin neurons
Pharmacol. Biochem. Behav.
(1988) - et al.
Regional distribution of monoamines in the cerebral cortex and subcortical structures of the rhesus: Concentration and in vivo synthesis rates
Brain Res.
(1979) - et al.
Orally administered MDMA causes a long-term depletion of serotonin in the rat brain
Brain Res.
(1988) - et al.
Acute effects of physostigmine on complex operant behavior in rhesus monkeys
Pharmacol. Biochem. Behav.
(1995) - et al.
Protein measurement with the Folin phenol reagent
J. Biol. Chem.
(1951) Use of the NCTR operant test battery in nonhuman primates
Neurotoxicol. Teratol.
(1990)- et al.
Monkey vs. human performance in the NCTR operant test battery
Neurotoxicol. Teratol.
(1990) - et al.
Toxic effects of MDMA on central serotonergic neurons in the primate: Importance of route and frequency of drug administration
Brain Res.
(1988) Discriminative profile of MDMA
Pharmacol. Biochem. Behav.
(1986)
Acute effects of d-amphetamine in a monkey operant behavioral test battery
Pharmacol. Biochem. Behav.
Effects of morphine sulfate on operant behavior in rhesus monkeys
Pharmacol. Biochem. Behav.
Multiple behavioral effects of diazepam in rhesus monkeys
Pharmacol. Biochem. Behav.
Neurochemical and Neurohistological alterations in the rat and monkey produced by orally administered methylenedioxymethamphetamine (MDMA)
Toxicol. Appl. Pharmacol.
Age-related susceptibility to MPTP-induced neurotoxicity
Neurotoxicol.
Oral administration of MDMA produces selective serotonergic neurotoxicity in rodents and nonhuman primates
SAAS Bull. Biochem. Biotech.
Persistent neurochemical and structural changes in rat brain after oral administration of MDMA
Res. Comm. Subst. Abuse
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2017, Progress in NeurobiologyCitation Excerpt :Although several studies clearly demonstrate the neurotoxic effects of MDMA in non-human primates, data on the behavioral and cognitive effects of MDMA in these animals are scarce. Some studies have suggested that no changes in a repeated acquisition tasks (Frederick et al., 1998; Winsauer et al., 2002) or in a battery of operant tasks (Frederick et al., 1995) occur in non-human primates exposed to varying dosing regimens of MDMA. See Table 1 for a summary of the protocols of the studies described above.
Human pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) after repeated doses taken 4h apart Human pharmacology of MDMA after repeated doses taken 4h apart
2015, European NeuropsychopharmacologyCitation Excerpt :A similar decrease in effects has been reported by many recreational users (Parrott, 2005). Rapid or acute tolerance has been observed in animals for both MDMA and other amphetamines after a second dose (Frederick et al.,1995), and in humans after the administration of two or more repeated doses of amphetamines (Pérez-Reyes et al., 1991; Comer et al., 2001). Acute tolerance in humans could be related to different mechanisms.
What are the specific vs. generalized effects of drugs of abuse on neuropsychological performance?
2011, Neuroscience and Biobehavioral ReviewsActions of 3,4-methylenedioxymethamphetamine (MDMA) on cerebral dopaminergic, serotonergic and cholinergic neurons
2008, Pharmacology Biochemistry and BehaviorTolerance to 3,4-methylenedioxymethamphetamine in rats exposed to single high-dose binges
2008, NeuroscienceCitation Excerpt :The blunted responsiveness to MDMA shown here agrees with previous reports of tolerance to diverse effects of MDMA in rats, including anorexia (Zacny et al., 1990), discriminative stimulus properties (Schechter, 1991; Virden and Baker, 1999), hyperthermia (Shankaran and Gudelsky, 1999; Piper et al., 2006) and locomotor activity (Callaway and Geyer, 1992; Brennan and Schenk, 2006). Tolerance to behavioral actions of MDMA is also well documented in non-human primates (Frederick et al., 1995; Frederick and Paule, 1997; Fantegrossi et al., 2004; Fantegrossi, 2007). On the other hand, a number of studies in rodents provide evidence for sensitized responsiveness after repeated MDMA exposure (Poland et al., 1997; Kalivas et al., 1998; Giorgi et al., 2005), suggesting tolerance development is not a universal outcome.
Effects of parametric feeding manipulations on behavioral performance in macaques
2004, Physiology and BehaviorCitation Excerpt :Unfortunately, the descriptions of the feeding restriction protocols employed in published studies are minimal. In a range of behavioral studies conducted in macaques, frequently no details are provided other than that animals were fed sufficient food to maintain motivation [15–17] or that animals were fed only after the testing sessions [18–24]. Some studies indicate that animals were fed “normal recommended diet” [25–29] or sufficient amounts to maintain body weight [19,30,31].