ArticleInterlaboratory comparison of motor activity experiments: Implications for neurotoxicological assessments☆
References (65)
Age-dependent effects of scopolamine on avoidance, locomotor activity, and rearing
Behav. Brain. Res.
(1982)Effects of scopolamine on locomotor activity and metabolic rate in mice
Pharmacol. Biochem. Behav.
(1987)Genetic differences in locomotor activation in mice
Pharmacol. Biochem. Behav.
(1986)- et al.
Effects of two pyrethroids on motor activity and the acoustic startle response in the rat
Toxicol. Appl. Pharmacol.
(1984) - et al.
The effects of Type I and Type II pyrethroids on motor activity and the acoustic startle response in the rat
Fundam. Appl. Toxicol.
(1988) - et al.
Hyperactivity induced by triadimefon, a triazole fungicide
Fundam. Appl. Toxicol.
(1988) - et al.
Validation of a photo-beam system for assessment of motor activity in rats
Toxicology
(1988) Superior colliculus involvement in the locomotor effects of ambient noise and the stimulants
Physiol. Behav.
(1983)- et al.
Behavioral effects of Pydrin and Ambush in male mice
Neurotoxicol. Teratol.
(1988) - et al.
Neurobehavioral effects of triadimefon, a triazole fungicide, in male and female rats
Neurotoxicol. Teratol.
(1989)
Hyperactive behavior of rats after lesions of the globus pallidus
Brain Res. Behav.
Development of nocturnal behavior in albino rats
Behav. Biol.
Motor activity changes and conditioned taste aversions induced by administration of scopolamine in rats: Role of the area postrema
Pharmacol. Biochem. Behav.
Acute behavioral toxicity of carbaryl and propoxur in adult rats
Pharmacol. Biochem. Behav.
Letter to the Editor: Comments on the number of experimental rats needed to test for motor activity
Toxicology
Two automated locomotor activity tests for dopamine autoreceptor agonists
Pharmacol. Biochem. Behav.
Behavioral indices of neurotoxicity: What can be measured?
Neurotoxicol. Teratol.
Effects of agonists and antagonists of cholinergic receptors on self-stimulation of the medial prefrontal cortex of the rat
Gen. Pharmacol.
Pharmacological studies with 7-benzyl-1-ethyl-1, 4-dihydro-4-oxo-1, 8-napththyridine- 3-carboxylic acid
J. Pharmacol. Exp. Ther.
Collaborative behavioral teratology study: Results
Neurobehav. Toxicol. Teratol.
Mechanism of selective action of pyrethroid insecticides
Annu. Rev. Pharmacol. Toxicol.
Comments on proposed test rule for glycol ethers by the Chemical Manufacturers Association
Fed. Reg.
The measurement of the influence of drugs on voluntary activity in mice
Br. J. Pharmacol.
Effects of drugs on spontaneous activity
Predicting neurotoxicity and behavioral dysfunction from preclinical toxicological data
A developmental neurotoxicity study protocol developed by the U.S. Environmental Protection Agency
Toxicologist
Comparison of the behavioral effects of neurotoxic and systemically toxic agents: How discriminatory are behavioral tests of neurotoxicity?
Neurobehav. Toxicol. Teratol.
Cholinergic influences on habituation of exploratory activity in mice
J. Comp. Physiol. Psychol.
Intercomparison study of the determination of single administration toxicity in rats
J. Ass. Off. Anal. Chem.
Uses and limitations of photocell activity cages for assessing effects of drugs
Psychopharmacologia
Observational batteries and motor activity
Zbl. Bakt. Hyg. (B)
Motor activity and screening for neurotoxicity
J. Am. Coll. Toxicol.
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The research described in this article has been reviewed by the Health Effects Research Laboratory, U.S. Environmental Protection Agency, and approved for publication. Approval does not signify that the contents necessarily reflect the views and policies of the Agency nor does mention of trade names or commercial products constitute endorsement or recommendation for use.
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Present address: Neurotoxicology Division, Health Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711.