Original contributionDistribution of spin-trapping compounds in rat blood and brain: In vivo microdialysis determination
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2018, Journal of Pharmaceutical and Biomedical AnalysisCitation Excerpt :Drug concentrations in brain dialysate reflect concentrations in brain extracellular fluid (ECF). To determine the transport characteristics of drug across the BBB, the free drug concentrations in blood should be detected in parallel to brain ECF concentrations [10]. A previous study has demonstrated that microdialysis is a useful tool for assessing local BBB transport profiles of boronophenylalanine-fructose (BPA-f) in glioma-bearing rats with FUS-induced BBB disruption [11].
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