The mouse CREB (cAMP responsive element binding protein) gene: Structure, promoter analysis, and chromosomal localization
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Cited by (34)
ATF-2 stimulates the human insulin promoter through the conserved CRE2 sequence
2007, Biochimica et Biophysica Acta - Gene Structure and ExpressionTranscription regulation of memory: CREB, CaMKIV, Fos/Jun, CBP, and SRF
2007, Learning and Memory: A Comprehensive ReferenceThe Role of CREB in Depression and Antidepressant Treatment
2006, Biological PsychiatryCitation Excerpt :With affinity chromatography, the CRE was shown to bind a protein in pheochromocytoma cell nuclear extracts, from which CREB protein was later purified (Montminy and Bilezikjian 1987). Subsequently, human, rat, and mouse complementary deoxyribonucleic acids (cDNAs) were cloned and exhibited remarkable sequence similarity, differing by one and two amino acids across species (Cole et al 1992; Gonzalez et al 1989; Hoeffler et al 1988). The mouse and human CREB genes are each composed of 11 exons, with alternative splicing of one or more exons to give rise to CREBα, CREBΔ, and CREBβ; the latter is a much less abundant isoform (Blendy et al 1996).
cAMP-response elements in Aplysia creb1, creb2, and Ap-uch promoters: Implications for feedback loops modulating long term memory
2005, Journal of Biological ChemistryCitation Excerpt :Activation of kinases to phosphorylate CREB2 may be required to promote dissociation of CREB2 from these CREs, thus facilitating the activation of creb1 by phosphorylated CREB1 protein. The promoter region of human creb also has three variant CREs, spread over nearly 800 bp (25), and that of mouse creb has one variant CRE (64). Neither region has a canonical CRE.
The Role of cAMP Response Element-Binding Proteins in Mediating Stress-Induced Vulnerability to Drug Abuse
2005, International Review of NeurobiologyCitation Excerpt :While CREB can be phosphorylated at several sites in its KID (Gonzalez et al., 1991), its phosphorylation at Ser 133 has been extensively studied and is believed to be important both for its DNA‐binding and transactivation properties (Cha‐Molstad et al., 2004). Mouse and human CREB genes contain 11 exons (Cole et al., 1992). CREB mRNA can be spliced in three alternative ways leading to CREB α, β, and Δ isoforms (Fig. 1B).
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Present address: Howard Hughes Medical Institute, University of California at Berkeley, Department of Molecular and Cell Biology, 401 Barker Hall, Berkeley, CA 94720.