Role of metals in oxygen radical reactions

doi:10.1016/0748-5514(85)90025-X

Journal of Free Radicals in Biology & Medicine

Volume 1, Issue 1, 1985, Pages 3-25

https://doi.org/10.1016/0748-5514(85)90025-X Get rights and content

Abstract

Partially-reduced forms of dioxygen or “oxy-radicals” (superoxide, $O_{2}^{⨪} HO_{2} ·$ ; hydrogen peroxide H₂O₂; hydroxyl radical ·OH) and oxidants of comparable reactivity are implicated in an increasing number of physiological, toxicological, and pathological states. Transition metal catalysis is recognized as being integral to the generation and the reactions of these activated oxygen species. Factors such as pH and chelation govern the reactivity of the transition metals with dioxygen and “oxy-radicals” and therefore influence the apparent mechanisms by which oxidative damage to phospholipids, DNA, and other biomolecules is initiated. In biological systems the concentrations of redox-active transition metals capable of catalyzing these reactions appears to be relatively low. However, under certain conditions metal storage and transport proteins (ferritin, transferrin, ceruloplasmin, etc.) may furnish additional redox active metals.

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Hypothesis paperRole of metals in oxygen radical reactions

Abstract

Biochim. Biophys. Acta

Biochim. Biophys. Acta

Inorg. Chim. Acta

Arch. Biochem. Biophys.

J. Biol. Chem.

J. Biol. Chem.

J. Biol. Chem.

Inorg. Chim. Acta

J. Biol. Chem.

Arch. Biochem. Biophys.

Biochem. Biophys. Res. Commun.

Arch. Biochem. Biophys.

Arch. Biochem. Biophys.

Arch. Biochem. Biophys.

FEBS Lett.

FEBS Lett.

FEBS Lett.

J. Biol. Chem.

Inorg. Chim. Acta

Arch. Biochem. Biophys.

Arch. Biochem. Biophys.

J. Biol. Chem.

Arch. Biochem. Biophys.

FEBS Lett.

Arch. Biochem. Biophys.

Kinetische untersuchung der autoxydation des in wasser gelösten ferrobicarbonats

Chem. Ber.

The kinetics of the oxygenation of ferrous iron in phosphoric acid solution

J. Am. Chem. Soc.

The kinetics of autoxidation of ferrous ions in concentrated HCl solutions

Trans. Faraday Soc.

The autoxidation of ferrous ions in aqueuos solution

Experientia

Oxidative Potentials

Chemical and physical properties of superoxide

The fitness of oxygen

The electromotive activation of oxygen

J. Am. Chem. Soc.

The oxidation of ferrous perchlorate by molecular oxygen

J. Chem. Soc.

The oxidation of solutions of ferrous salts

J. Phys. Chem.

Detection and characterization of the long-postulated FeOOFe intermediate in the autoxidation of ferrous porphyrins

J. Am. Chem. Soc.

Komplexone XVIII. Die eisen(II)- und eisen(III)-komplexe des äthylenediamintetraessigsäure und ihr redoxgleichgewicht

Helv. Chim. Acta

Oxygen oxidation of ferrous ions induced by chelation

Bull. Chem. Soc. Jap.

The kinetics of the autoxidation of ferrous ions in aqueous tripolyphosphate solutions

Bull. Chem. Soc. Jap.

Determination of nonheme iron, total iron and copper

The mechanism of oxygenation of ferrous ion in neutral solution

Inorg. Chem.

Model studies on the binding of univalent and redox-active copper in proteins

Interactions of Cu(I) complexes with dioxygen

The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase

J. Biol. Chem.

Generation of hydrogen peroxide, superoxide and hydroxyl radicals during the oxidation of dihydroxyfumaric acid by peroxidase

Biochem. J.

Kinetics of the reaction of molecular oxygen with iron(III)-cysteine complexes

J. Chem. Soc.

Hypothesis paper
Role of metals in oxygen radical reactions