ArticleSDZ-205,152, a novel dopamine receptor agonist, reduces oral ethanol self-administration in rats
References (44)
- et al.
Actions of drugs of abuse on brain reward systems: A reconsideration with specific attention to alcohol
Pharmacol. Biochem. Behav.
(1982) - et al.
Ethanol increases the firing rate of dopamine neurons of the rat ventral tegmental area in vitro
Brain Res.
(1990) - et al.
The effects of selective catecholamine depletions by 6-hydroxydopamine on ethanol preference in rats
Neurosci. Lett.
(1977) - et al.
Lack of effect of dopamine receptor blockade on voluntary ethanol consumption in rats
Behav. Neural Biol.
(1982) - et al.
Forebrain noradrenaline and oral self-administration of ethanol by rats
Behav. Brain Res.
(1983) - et al.
Attenuation of antidepressant drugs of alcohol intake in rats
Alcohol
(1984) - et al.
Reinforcement with intragastric infusions of ethanol: Blocking effect of FLA-57
Pharmacol. Biochem. Behav.
(1979) - et al.
Suppression of voluntary ethanol consumption in rats by gammabutyrolactone
Life Sci.
(1983) - et al.
Effects of spontaneous ingestion of ethanol on brain dopamine metabolism
Life Sci.
(1989) - et al.
Postsynaptic dopamine/adenosine interaction: I. Adenosine analogues inhibit dopamine D2-mediated behavior in short-term reserpinized mice
Eur. J. Pharmacol.
(1991)
Low doses of ethanol activate dopaminergic neurons of the ventral tegmental area
Brain Res
Opioidergic, serotonergic and dopaminergic manipulations and rats' intake of a sweetened alcoholic beverage
Alcohol
Amphetamine and apomorphine responses in the rat following 6-OHDA lesions of the nucleus accumbens septi and corpus striatum
Brain Res.
Effects of Ro-15-4513, fluoxetine and desipramine on the intake of ethanol, water and food by the alcohol-preferring (P) and non-preferring (NP) lines of rats
Pharmacol. Biochem. Behav.
Serotonin, dopamine and GABA involvement in alcohol drinking of selectively bred rats
Alcohol
Methadone, pentobarbital, pimozide and ethanol-intake
Alcohol
Effects of fluoxetine on the intragastric self-administration of ethanol in the alcohol preferring P line of rats
Alcohol
A neuroanatomical substrate for alcohol drinking: Identification of tetrahydropapaveroline (THP)-reactive sites in rat brain
Brain Res. Bull.
Oral ethanol reinforcement in the rat: Effects of acute amphetamine
Alcohol
Effect of pimozide on home cage ethanol drinking in the rat: Dependence on drinking session length
Drug Alc. Depend
Haloperidol and apomorphine effects on ethanol reinforcement in free feeding rats
Pharmacol. Biochem. Behav.
Naloxone, but not Tyr-MIF-1, reduces volitional ethanol drinking in rats: Correlation with degree of spontaneous preferences
Pharmacol. Biochem. Behav.
Cited by (58)
Alcohol: Neurobiology of Addiction
2021, Alcohol: Neurobiology of AddictionDopamine and opioid systems adaptation in alcoholism revisited: Convergent evidence from positron emission tomography and postmortem studies
2019, Neuroscience and Biobehavioral ReviewsCitation Excerpt :For example, using chronic intermittent access, every second day, to a highly concentrated (e.g. 20%) ethanol solution under operant or non-operant conditions has been reported to result in an increase from about 2 g ethanol to roughly 6 g/kg/d (Simms et al., 2008; Wise, 1973). High peak blood alcohol levels of more than 100 mg/dl may be reached, but only for brief periods (Carnicella et al., 2014; Rassnick et al., 1993). Another paradigm to increase voluntary intake of alcohol is genetic selection for high alcohol preference.
Effects of DA-Phen, a dopamine-aminoacidic conjugate, on alcohol intake and forced abstinence
2016, Behavioural Brain ResearchCitation Excerpt :From this point of view, our results are in line with those reported on a DA modulator (SDZ-205,152) administration, which has been demonstrated its efficacy in decreasing orally self-administer ethanol (10% w/v) intake in a free-choice, two-lever operant task. This modulator, at doses of 0.5–5.0 mg/kg subcutaneously administered 30 min prior operant task, was able to selectively reduced ethanol-reinforced responding without altering responses for water [18]. Overall DA-Phen effects can result from its role as DA modulator, as they highlight the DAergic matrix of related behavioral outcomes.
Cell type-specific synaptic encoding of ethanol exposure in the nucleus accumbens shell
2014, NeuroscienceCitation Excerpt :However, since the degree of change is small and LTD was still readily apparent, the main conclusion is that neither strong activation nor blockade of D1 receptors has a dramatic effect on LFS LTD expression in the slice preparation. Since D1 receptor antagonists have been shown to reduce operant responding for ethanol (Rassnick et al., 1993; Samson et al., 1993), it remains that in the intact animal where DA tone is fully present, modulation of LTD in D1+ MSNs may constitute a synaptic mechanism through which the NAc circuitry is altered to facilitate ethanol consumption. Nonetheless, the role of basal D1 receptor activation in vivo since we have previously documented that D1-receptor activation can significantly diminish NMDA receptor sensitivity to ethanol and thereby even modulate the ability of ethanol to inhibit NMDA 1-Hz LTD (Maldve et al., 2002; Zhang et al., 2005; Jeanes et al., 2011).
Alcohol: Mechanisms along the mesolimbic dopamine system
2014, Progress in Brain ResearchCitation Excerpt :Supportively, dopamine antagonists suppress the alcohol locomotor stimulation in rats (Liljequist et al., 1981). Moreover, several studies have reported alterations in alcohol intake, preference, and oral self-administration following systemic and intra-accumbal administration of dopamine agonists or antagonists (Hodge et al., 1997; McBride et al., 1988, 1990; Nowak et al., 2000; Pfeffer and Samson, 1985a,b, 1988; Rassnick et al., 1993a,b,c; Samson et al., 1991; Weiss et al., 1990). In addition, the rewarding properties of addictive drugs are attenuated by a decreased dopaminergic neurotransmission (Maldonado et al., 1997; Risinger et al., 2000; Wise, 1996).
Synthesis and pharmacological evaluation of 6-naltrexamine analogs for alcohol cessation
2009, Bioorganic and Medicinal Chemistry
- 1
Visiting Scientist from The 3rd Department of Neurology, University of Pavia, Italy.