Specific decreases in ethanol- but not water-reinforced responding produced by the 5-HT3 antagonist ICS 205-930

doi:10.1016/0741-8329(93)90034-L

Alcohol

Volume 10, Issue 3, May–June 1993, Pages 191-196

https://doi.org/10.1016/0741-8329(93)90034-L Get rights and content

Abstract

The serotonin 5-HT₃ antagonist ICS 205–930 has been shown to block the discriminative stimulus properties of ethanol and decrease voluntary intake, suggesting a possible role for 5-HT₃ systems in the reinforcing effects of ethanol. ICS 205–930 (0.56, 1.0, 3.0, 10.0, and 17.0 mg/kg i.p.) was examined on ethanol and water self-administration in an operant paradigm. Following a sucrose-fading procedure, two groups of nondeprived rats responded on either a concurrent fixed ratio 4 schedule for ethanol (10% v/v) and water (CONC FR4 FR4), or a single FR4 schedule for ethanol (10% v/v). ICS 205–930 dose-dependently decreased ethanol-reinforced responding in the concurrent condition without decreasing water-reinforced responding, suggesting a specific effect on ethanol. Ethanol-reinforced responding was also dose-dependently decreased in the single FR4 condition, but the dose effect curve was shifted to the left. These data support the conclusions that 5-HT₃ systems may play a specific role in ethanol self-administration that is independent of general appetitive and motor processes, and that 5-HT₃ antagonists may have therapeutic efficacy in the treatment of alcohol abuse when multiple reinforcers are available.

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ArticleSpecific decreases in ethanol- but not water-reinforced responding produced by the 5-HT3 antagonist ICS 205-930

Abstract

Eur. J. Pharmacol.

Eur. J. Pharmacol.

Pharmacol. Biochem. Behav.

Alcohol

Alcohol

Pharmacol. Biochem. Behav.

Pharmacol. Biochem. Behav.

Neurosci. Lett.

Pharmacol. Biochem. Behav.

Alcohol

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Alcohol

Eur. J. Pharmacol.

Neuropharmacology

Eur. J. Pharmacol.

Eur. J. Pharmacol.

Pharmacol. Biochem. Behav.

Identification of 5-HT3 recognition sites in human brain tissue using [3H]Zacopride

J. Pharm. Pharmacol.

Release of endogenous dopamine by stimulation of 5-Hydroxytryptamine3 receptors in rat striatum

J. Pharmacol. Exp. Ther.

Ingestive responses following benzodiazapine receptor ligands, selective 5-HT1A agonists and selective 5-HT3 receptor antagonists

Article
Specific decreases in ethanol- but not water-reinforced responding produced by the 5-HT₃ antagonist ICS 205-930

Identification of 5-HT₃ recognition sites in human brain tissue using [³H]Zacopride

Release of endogenous dopamine by stimulation of 5-Hydroxytryptamine₃ receptors in rat striatum

Ingestive responses following benzodiazapine receptor ligands, selective 5-HT_1A agonists and selective 5-HT₃ receptor antagonists